Evidence map›Paper›PMID 34829395›Full record

ArticleDiagnostics (Basel, Switzerland)2021

A Predictive Clinical-Radiomics Nomogram for Survival Prediction of Glioblastoma Using MRI.

Samy Ammari, Raoul Sallé de Chou, Corinne Balleyguier, Emilie Chouzenoux, Mehdi Touat, Arnaud Quillent, Sarah Dumont, Sophie Bockel, Gabriel C T E Garcia, Mickael Elhaik and 5 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Samy AmmariBiomaps, UMR1281 INSERM, CEA, CNRS, Université Paris-Saclay, 94805 Villejuif, France.ORCID 0000-0002-1506-0714
Raoul Sallé de ChouBiomaps, UMR1281 INSERM, CEA, CNRS, Université Paris-Saclay, 94805 Villejuif, France.
Corinne BalleyguierBiomaps, UMR1281 INSERM, CEA, CNRS, Université Paris-Saclay, 94805 Villejuif, France.
Emilie ChouzenouxCentre de Vision Numérique, OPIS, CentraleSupélec, Inria, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.
Mehdi TouatService de Neurologie 2-Mazarin, AP-HP Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, 75013 Paris, France.ORCID 0000-0002-5910-7799
Arnaud QuillentCentre de Vision Numérique, OPIS, CentraleSupélec, Inria, Université Paris-Saclay, 91190 Gif-sur-Yvette, France.ORCID 0000-0001-6358-1293
Sarah DumontDepartment of oncology, Gustave Roussy, Université Paris Saclay, 94805 Villejuif, France.
Sophie BockelDepartment of Radiation Oncology, Gustave Roussy Cancer Campus, 94800 Villejuif, France.
Gabriel C T E GarciaDepartment of Imaging, Gustave Roussy, Université Paris Saclay, 94805 Villejuif, France.
Mickael ElhaikBiomaps, UMR1281 INSERM, CEA, CNRS, Université Paris-Saclay, 94805 Villejuif, France.
Bidault FrancoisBiomaps, UMR1281 INSERM, CEA, CNRS, Université Paris-Saclay, 94805 Villejuif, France.
Valentin BorgetBiomaps, UMR1281 INSERM, CEA, CNRS, Université Paris-Saclay, 94805 Villejuif, France.
Nathalie LassauBiomaps, UMR1281 INSERM, CEA, CNRS, Université Paris-Saclay, 94805 Villejuif, France.
Mohamed KhettabMedical Oncology Unit, CHU de La Réunion, Université de La Réunion, 97410 Saint Pierre, France.ORCID 0000-0002-3345-4901
Tarek AssiDepartment of oncology, Gustave Roussy, Université Paris Saclay, 94805 Villejuif, France.
Centre National de la Recherche Scientifique · FRUniversité Paris-Saclay · FRCentre Hospitalier Universitaire de La Réunion · FRInstitut Gustave Roussy · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adult patients with a median survival of around one year. Prediction of survival outcomes in GBM patients could represent a huge step in treatment personalization. The objective of this study was to develop machine learning (ML) algorithms for survival prediction of GBM patient. We identified a radiomic signature on a training-set composed of data from the 2019 BraTS challenge (210 patients) from MRI retrieved at diagnosis. Then, using this signature along with the age of the patients for training classification models, we obtained on test-sets AUCs of 0.85, 0.74 and 0.58 (0.92, 0.88 and 0.75 on the training-sets) for survival at 9-, 12- and 15-months, respectively. This signature was then validated on an independent cohort of 116 GBM patients with confirmed disease relapse for the prediction of patients surviving less or more than the median OS of 22 months. Our model insured an AUC of 0.71 (0.65 on train). The Kaplan-Meier method showed significant OS difference between groups (log-rank

Indexed as

biomarkerglioblastomamachine learningradiomics

Identifiers

PMID34829395
PMCPMC8624566
OpenAlexW3209298051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.