Evidence map›Paper›PMID 34829316›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Mutational Analysis and mtDNA Haplogroup Characterization in Three Serbian Cases of Mitochondrial Encephalomyopathies and Literature Review.

Phepy G A Dawod, Jasna Jancic, Ana Marjanovic, Marija Brankovic, Milena Jankovic, Janko Samardzic, Ayman Gamil Anwar Dawod, Ivana Novakovic, Fayda I Abdel Motaleb, Vladimir Radlovic and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. On the Edge of Empire: Paleogenomic Insights into Roman Dacia.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Phepy G A DawodFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0003-4765-6675
Jasna JancicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Ana MarjanovicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Marija BrankovicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Milena JankovicNeurology Clinic, Clinical Center of Serbia, 11000 Belgrade, Serbia.ORCID 0000-0002-3939-9739
Janko SamardzicInstitute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-8464-4924
Ayman Gamil Anwar DawodInternal Medicine, Hepatogastroenterology and Endoscopy Department, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt.
Ivana NovakovicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Fayda I Abdel MotalebDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo 11591, Egypt.
Vladimir RadlovicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Vladimir S KosticFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Dejan NikolicFaculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0002-0609-9916
University of Belgrade · RSAin Shams University · EGCentar za Promociju Nauke · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial encephalomyopathies (MEMP) are heterogeneous multisystem disorders frequently associated with mitochondrial DNA (mtDNA) mutations. Clinical presentation varies considerably in age of onset, course, and severity up to death in early childhood. In this study, we performed molecular genetic analysis for mtDNA pathogenic mutation detection in Serbian children, preliminary diagnosed clinically, biochemically and by brain imaging for mitochondrial encephalomyopathies disorders. Sanger sequencing analysis in three Serbian probands revealed two known pathogenic mutations. Two probands had a heteroplasmic point mutation m.3243A>G in the

Indexed as

haplogroupsleigh syndromeMELASmtDNAmutationssanger sequencing

Identifiers

PMID34829316
PMCPMC8620769
OpenAlexW3208955516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.