Evidence map›Paper›PMID 34829293›Full record

ArticleDiagnostics (Basel, Switzerland)2021

High Pregnane X Receptor (PXR) Expression Is Correlated with Poor Prognosis in Invasive Breast Carcinoma.

Stamatios Theocharis, Constantinos Giaginis, Stefania Gourzi, Paraskevi Alexandrou, Gerasimos Tsourouflis, Panagiotis Sarantis, Eugene Danas, Artemis Michail, Nikolaos Tsoukalas, Alexandros Pergaris and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Stamatios TheocharisFirst Department of Pathology, Medical School, University of Athens, 11527 Athens, Greece.
Constantinos GiaginisDepartment of Food Science and Nutrition, University of the Aegean, 81400 Lemnos, Greece.ORCID 0000-0003-2878-4831
Stefania GourziFirst Department of Pathology, Medical School, University of Athens, 11527 Athens, Greece.
Paraskevi AlexandrouFirst Department of Pathology, Medical School, University of Athens, 11527 Athens, Greece.
Gerasimos TsourouflisFirst Department of Pathology, Medical School, University of Athens, 11527 Athens, Greece.
Panagiotis SarantisFirst Department of Pathology, Medical School, University of Athens, 11527 Athens, Greece.ORCID 0000-0001-5848-7905
Eugene DanasFirst Department of Pathology, Medical School, University of Athens, 11527 Athens, Greece.
Artemis MichailSection of Molecular Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.
Nikolaos TsoukalasFirst Department of Pathology, Medical School, University of Athens, 11527 Athens, Greece.ORCID 0000-0002-1455-1503
Alexandros PergarisFirst Department of Pathology, Medical School, University of Athens, 11527 Athens, Greece.ORCID 0000-0002-4960-672X
Panagiotis K PolitisSection of Molecular Biology, Biomedical Research Foundation, Academy of Athens, 11527 Athens, Greece.
Lydia NakopoulouFirst Department of Pathology, Medical School, University of Athens, 11527 Athens, Greece.
National and Kapodistrian University of Athens · GRAcademy of Athens · GRUniversity of the Aegean · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnane X Receptor (PXR) is involved in human cancer, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance. The clinical significance of PXR expression in invasive breast carcinoma was evaluated in the present study. PXR protein expression was assessed immunohistochemically on formalin fixed paraffin-embedded breast invasive carcinoma tissue sections, obtained from 148 patients, and was correlated with clinicopathological parameters, molecular phenotypes, tumor cells' proliferative capacity, and overall disease-free patients' survival. Additionally, the expression of PXR was examined on human breast carcinoma cell lines of different histological grade, hormonal status, and metastatic potential. PXR positivity was noted in 79 (53.4%) and high PXR expression in 48 (32.4%), out of 148 breast carcinoma cases. High PXR expression was positively associated with nuclear grade (

Indexed as

breast cancercell linesclinicopathological parametersimmunohistochemistrypatients’ prognosisPXR

Identifiers

PMID34829293
PMCPMC8624096
OpenAlexW3207810075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.