ArticleChildren (Basel, Switzerland)2021
Long-Term Outcomes after Neonatal Hypoxic-Ischemic Encephalopathy in the Era of Therapeutic Hypothermia: A Longitudinal, Prospective, Multicenter Case-Control Study in Children without Overt Brain Damage.
Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Therapeutic hypothermia in newborns: evidence-based guidelines from a systematic review.Italian journal of pediatrics · 2026Pooled it
- Temporal evolution of electrographic seizures in newborn infants with hypoxic-ischaemic encephalopathy requiring therapeutic hypothermia: a secondary analysis of the ANSeR studies.The Lancet. Child & adolescent health · 2024Trial
- Feasibility and Temperature Stability of Low-Complexity Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: A Retrospective Case Series.AJP reports · 2026Article
- Prognostic value of Cranial Ultrasound combined with Serum Neuron-Specific Enolase and Creatine Kinase-MB Isoenzyme Measurement in Neonatal Hypoxic-Ischemic Encephalopathy.Pakistan journal of medical sciences · 2026Article
- Mitochondrial dysfunction in neonatal brain injury: from molecular mechanisms to therapeutic interventions.Journal of translational medicine · 2026Review
- Hypoxic-Ischemic Encephalopathy in Newborns: Pathophysiology, Early Identification, and Management.Cureus · 2026Review
- Shifting outlooks after neonatal encephalopathy in the era of therapeutic hypothermia.Pediatric research · 2025Review
- School outcomes after HIE: a population-based cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2025Article
- Extracellular vesicles and preterm infant diseases.Frontiers in pediatrics · 2025Review
- Traditional and non-traditional behavioral tests demonstrate the attenuation of cognitive deficits by therapeutic hypothermia in a rat model of neonatal hypoxic-ischemic encephalopathy.Frontiers in behavioral neuroscience · 2025Article
- Inflammation mediated brain damage and cytokine expression in a maternally derived murine model for preterm hypoxic-ischemic encephalopathy.Frontiers in systems biology · 2025Article
- Neonatal hypoxia: impacts on the developing mind and brain.Frontiers in cognition · 2025Review
- Neonatal hypoxia-ischemia alters the events governing the hippocampal critical period of postnatal synaptic plasticity leading to deficits in working memory in mice.Neurobiology of disease · 2024Article
- A Predictive Model for Perinatal Brain Injury Using Machine Learning Based on Early Birth Data.Children (Basel, Switzerland) · 2024Article
- Psychometric properties of the Parenting Stress Index-Short Form in a Peruvian sample.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2024Article
- TrkB-mediated sustained neuroprotection is sex-specific and Erα-dependent in adult mice following neonatal hypoxia ischemia.Biology of sex differences · 2024Article
- Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury.Journal of neuroinflammation · 2023Article
- Outcome at early school age and adolescence after hypothermia-treated hypoxic-ischaemic encephalopathy: an observational, population-based study.Archives of disease in childhood. Fetal and neonatal edition · 2023Observational
- Long-term consequences of neonatal encephalopathy in the hypothermia era: protocol for a follow-up cohort study at 9 years of age.BMJ open · 2023Article
- Analgesia and sedation strategies in neonates undergoing whole-body therapeutic hypothermia: A scoping review.PloS one · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundData on long-term outcomes in the era before therapeutic hypothermia (TH) showed a higher incidence of cognitive problems. Since the introduction of TH, data on its results are limited.
methodsOur sample population consisted of 40 children with a history of hypoxic-ischemic encephalopathy (HIE) treated with TH, with an average age of 6.25 years (range 5.5, 7.33), 24 (60%) males; and 33 peers with an average age of 8.8 years (6.08, 9.41), 17 (51%) males. Long-term follow-up data belong to two centers in Padova and Torino. We measured general intelligence (WPPSI-III or WISC-IV) and neuropsychological functioning (language, attention, memory, executive functions, social skills, visual motor abilities). We also administered questionnaires to their parents on the children's psychopathological profiles and parental stress.
resultsWe found differences between groups in several cognitive and neuropsychological domains: intelligence, visuomotor skills, executive functions, and attention. Interestingly, IQ test results effectively differentiated between the groups (HIE vs. controls). Furthermore, the incidence of psychopathology appears to be significantly higher in children with HIE (35%) than in control peers (12%).
conclusionsOur study supports previous findings on a higher incidence of neuropsychological, cognitive, and psychopathological sequelae after HIE treated with TH. As hypothesized, TH does not appear to ameliorate the outcome after neonatal HIE in those children who survive without major sequelae.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.