ArticleChildren (Basel, Switzerland)2021
Cardiothoracic CTA in Infants Referred for Aortic Arch Evaluation-Retrospective Comparison of Iomeprol 350, Ioversol 350, Iopromide 370 and Iodixanol 320.
Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 10 citations in OpenAlex.
- Development and validation of a stability-indicating high-performance liquid chromatography method for iomeprol.Scientific reports · 2026Article
- Thoracic CT Angiographies in Children Using Automated Power Injection with Bolus Tracking Versus Manual Contrast Injection: Analysis of Contrast Enhancement, Image Quality and Radiation Exposure.Diagnostics (Basel, Switzerland) · 2025Article
- Advances in the Diagnosis and Management of Congenital Heart Disease in Children.Children (Basel, Switzerland) · 2023Article
- Comparing the Diagnostic Performance of ECG Gated versus Non-Gated CT Angiography in Ascending Aortic Dissection: A GRRAS Study.Tomography (Ann Arbor, Mich.) · 2022Article
- Detection of Coronary Artery and Aortic Arch Anomalies in Patients with Tetralogy of Fallot Using CT Angiography.Journal of clinical medicine · 2022Article
- Advances in the Diagnosis and Management of Congenital Heart Disease in Children.Children (Basel, Switzerland) · 2022Article
- Reply to Nyman, U.; Aspelin, P. Regarding Iodixanol for Pediatric CTA. Comment on "Pop, M. Cardiothoracic CTA in Infants Referred for Aortic Arch Evaluation-Retrospective Comparison of Iomeprol 350, Ioversol 350, Iopromide 370 and Iodixanol 320.Children (Basel, Switzerland) · 2022Article
- Regarding Iodixanol for Pediatric CTA. Comment on Pop, M. Cardiothoracic CTA in Infants Referred for Aortic Arch Evaluation-Retrospective Comparison of Iomeprol 350, Ioversol 350, Iopromide 370 and Iodixanol 320.Children (Basel, Switzerland) · 2022Article
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Authors and funding
1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundComputed tomography angiography (CTA) in infants is considered one of the most challenging radiological examinations due to difficulties in balancing start delay, contrast agent (CA) volume and flow in order to achieve optimal opacification of the large vessels. This study aimed to compare the contrast enhancement achieved by four CAs when taking into consideration CA injection parameters and patient characteristics.
methodsWe performed a retrospective assessment of forty-eight consecutive cardiothoracic CTAs performed for aortic arch evaluation on children aged 0-1 year. All examinations were performed using the same 64-slice scanner and power injector using the bolus tracking technique. Axial 0.6 mm slices were used to measure large vessel enhancement using regions of interest at the level of the main pulmonary artery, ascending and descending aorta. The recorded variables included anthropometric measurements, CA type, flow rate, volume, and the average Hounsfield unit (HU) values of the blood pool. Descriptive statistics are presented as averages and standard deviations (SD) for normal distributed data or otherwise as medians and interquartile ranges (IQRs).
resultsWe found no statistically significant differences between age and anthropometric parameters when looking at different CAs. The median CA volume was 7 (IQR, 7-9) mL with the average flow rate of 0.94 (SD, 0.23) mL/s. Ascending aorta average HU values were 605.9 (SD, 177.23) for Iomeprol 350, 626 (SD, 183.83) for Ioversol 350, 530.83 (SD, 175.56) for Iopromide 370 and 354.91 (SD, 115.81) for Iodixanol 320. The difference in HU value for Iodixanol 320 compared to the other CAs was statistically significant. Similar differences were found for the other vascular structures.
conclusionIn CTA of infants suspected of aortic arch hypoplasia/coarctation, Iodixanol 320 provided up to 40% less enhancement of the great vessels when compared to Iomeprol 350, Ioversol 350 and Iopromide 370.
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