ArticleChildren (Basel, Switzerland)2021
Higher versus Lower Oxygen Concentration during Respiratory Support in the Delivery Room in Extremely Preterm Infants: A Pilot Feasibility Study.
Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03706586 (Is the Use of Higher Versus Lower Oxygen Concentration Feasible in the Delivery Room), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is the Use of Higher Versus Lower Oxygen Concentration Feasible in the Delivery Room: a Pilot Trial
Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Article
- Optimizing Care for the Preterm Infant.Children (Basel, Switzerland) · 2022Article
- Neonatal Resuscitation in Children 2021: Focus on Training, Technology, and New Clinical Approaches.Children (Basel, Switzerland) · 2022Article
- Effects of Arterial Carbon Dioxide Tension on Cerebral and Somatic Regional Tissue Oxygenation and Blood Flow in Neonates After the Norwood Procedure With Deep Hypothermic Cardiopulmonary Bypass.Frontiers in pediatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOptimal starting oxygen concentration for delivery room resuscitation of extremely preterm infants (<29 weeks) remains unknown, with recommendations of 21-30% based on uncertain evidence. Individual patient randomized trials designed to answer this question have been hampered by poor enrolment. HYPOTHESIS: It is feasible to compare 30% vs. 60% starting oxygen for delivery room resuscitation of extremely preterm infants using a change in local hospital policy and deferred consent approach. STUDY
designProspective, single-center, feasibility study, with each starting oxygen concentration used for two months for all eligible infants. POPULATION: Infants born at 23 + 0-28 + 6 weeks' gestation who received delivery room resuscitation. Study interventions: Initial oxygen at 30% or 60%, increasing by 10-20% every minute for heart rate < 100 bpm, or increase to 100% for chest compressions. PRIMARY OUTCOME: Feasibility, defined by (i) achieving difference in cumulative supplied oxygen concentration between groups, and (ii) post-intervention rate consent >50%.
resultsThirty-four infants were born during a 4-month period; consent was obtained in 63%. Thirty (
conclusionRandomized control trial of 30% or 60% oxygen at the initiation of resuscitation of extremely preterm neonates with deferred consent is feasible.
trial registrationClinicaltrials.gov NCT03706586.
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