Evidence map›Paper›PMID 34828526›Full record

ArticleHealthcare (Basel, Switzerland)2021

The Relationship between the Second-Generation Antipsychotics Efficacy and the Traditional Chinese Medicine Body Constitutions in Patients with Schizophrenia.

Tzu-Pei Yeh, Li-Chi Huang, Yu-Fen Chen, Jui-Fen Cheng

Abstract read
In one paragraph

Article in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tzu-Pei YehSchool of Nursing, China Medical University, Taichung 406040, Taiwan.ORCID 0000-0002-2620-0591
Li-Chi HuangSchool of Nursing, China Medical University, Taichung 406040, Taiwan.ORCID 0000-0003-1152-6596
Yu-Fen ChenDepartment of Nursing, Taichung Veterans General Hospital, Taichung 40705, Taiwan.ORCID 0000-0002-2625-2551
Jui-Fen ChengSchool of Nursing, China Medical University, Taichung 406040, Taiwan.

Funding

China Medical University CMU104-S-54
6 · The paper itself

Abstract

backgroundSchizophrenia requires lifelong treatment; Second-generation Antipsychotics (SGAs) have become the most prescribed medication for schizophrenia patients. The efficacy of various SGAs treatment may differ in schizophrenia patients with various traditional Chinese medicine (TCM) body constitution (BC) types.

methodThis study applied a longitudinal quantitative research design, where a total of 66 participants were recruited. The Positive and Negative Symptom Scale (PANSS) and the Clinical Global Impression (CGI) score were used to evaluate patients' psychopathology status in hospitalization, and body constitution questionnaires were conducted by face-to-face interviews in the 1st, 3rd, and 6th week of hospitalization.

resultsMore than 60% of schizophrenia patients who were treated with SGAs were classified to have unbalanced BC types including Yin-Xu, Yang-Xu and Stasis. Generalized estimating equation analysis revealed significant time effects in CGI and PANSS score improvements in both unbalanced and gentleness (balance) BC types, but no significant changes in the group and group-time interaction in the CGI and PANSS scores in different BC type groups.

conclusionsSchizophrenia patients under SGAs treatment had a higher proportion of unbalanced BC types which may lead to poorer physical or mental statuses, such as overweight problems. Health care providers could apply interventions according to patients' BC types for disease prevention.

Indexed as

body constitutionsschizophreniasecond-generation antipsychoticstraditional Chinese medicine

Identifiers

PMID34828526
PMCPMC8622047

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