ReviewHealthcare (Basel, Switzerland)2021
Long-Term Effect of Exercise on Irisin Blood Levels-Systematic Review and Meta-Analysis.
Review in Healthcare (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Effects of Different Training Modalities on Circulating Irisin Levels in Overweight and Obesity Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Comparative effects of different exercise modalities on cognitive domains in older adults: a Bayesian network meta-analysis and meta-regression.Frontiers in nutrition · 2026Pooled it
- Effects of aerobic exercise on cognitive function in older adults with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Research hotspots of irisin in the nervous system: a bibliometric study and visualization analysis via CiteSpace.Frontiers in aging neuroscience · 2025Pooled it
- Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis.Updates in surgery · 2024Pooled it
- Pooled it
- The Effect of Two Somatic-Based Practices Dance and Martial Arts on Irisin, BDNF Levels and Cognitive and Physical Fitness in Older Adults: A Randomized Control Trial.Clinical interventions in aging · 2024Trial
- Fall-Related Physical Function, Executive Function, and Myokine Responses in Older Women with Obesity Participating in a 16-Week Combined Aquatic Exercise Program: A Prospective Observational Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Comparative Effects of Sertraline, Methotrexate, and Biologic Therapies on Circulating Inflammatory and Neurotrophic Mediators and Striatal Gene Expression in Collagen-Induced Arthritis.International journal of molecular sciences · 2026Article
- Muscle-Tumor Crosstalk in Exercise Oncology: Exercise-Induced Myokines and Cancer Cachexia.Cancers · 2026Review
- Therapeutic effects of Tetramethylpyrazine on Cartilage in Rat Model of Post-traumatic Osteoarthritis.Regenerative therapy · 2026Article
- Molecular and Physiological Adaptations to Seasonal Training in Elite U18 Ice Hockey Players.Sports (Basel, Switzerland) · 2026Article
- Exercise-Induced Molecular Adaptations in Chronic Non-Communicable Diseases-Narrative Review.International journal of molecular sciences · 2025Review
- Optimal exercise modalities and dose selection to reduce leptin levels in overweight or obese individuals: a network meta-analysis and dose-response relationship study.BMC sports science, medicine & rehabilitation · 2025Article
- The role of irisin in exercise-induced muscle and metabolic health: a narrative review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Health benefits of physical activity: What role does skeletal muscle-organ crosstalk play?Sports medicine and health science · 2025Review
- Exercise-regulated lipolysis: Its role and mechanism in health and diseases.Journal of advanced research · 2025Review
- Aerobic exercise-induced changes in fluid biomarkers in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- Padua Days on Muscle and Mobility Medicine, March 25-29, 2025, Hotel Petrarca, Euganean Thermae, Italy: Program and Abstracts.European journal of translational myology · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physical exercise may activate a number of important biochemical processes in the human body. The aim of this systematic review and meta-analysis was to identify the long-term effect of physical activity on irisin blood levels. We searched PubMed, Scopus, and Web of Science for articles addressing the long-term effect of physical exercise on irisin blood levels. Fifty-nine articles were included in the final qualitative and quantitative syntheses. A statistically significant within-group effect of exercise on irisin blood levels was in 33 studies; out of them, the irisin level increased 23× and decreased 10×. The significant positive between-groups effect was found 11×. Furthermore, the meta-analysis indicated that physical exercise had a significant positive effect on irisin blood levels (SMD = 0.39 (95% CI 0.27-0.52)). Nevertheless, considerably high heterogeneity was found in all the analyses. This systematic review and meta-analysis indicate that physical exercise might increase irisin blood levels; however, the results of individual studies were considerably inconsistent, which questions the methodological detection of irisin by ELISA kits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.