Evidence map›Paper›PMID 34828440›Full record

ArticleGenes2021

Krzysztof Chmielowiec, Jolanta Chmielowiec, Jolanta Masiak, Małgorzata Czekaj, Piotr Krawczyk, Ewelina Soroka, Małgorzata Śmiarowska, Wojciech Musiał, Tomasz Pawłowski, Anna Grzywacz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. The 7-Repeat (7R) Variant of theInternational journal of molecular sciences · 2025
    Article
  2. Association of Polymorphism within the Putative miRNA Target Site in the 3'UTR Region of theInternational journal of environmental research and public health · 2022
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Krzysztof ChmielowiecDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland.ORCID 0000-0003-4254-5466
Jolanta ChmielowiecDepartment of Hygiene and Epidemiology, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland.ORCID 0000-0003-3285-5313
Jolanta MasiakSecond Department of Psychiatry and Psychiatric Rehabilitation, Medical University of Lublin, 1 Głuska St., 20-059 Lublin, Poland.
Małgorzata CzekajDepartment of Nervous System Diseases, Orthopedics, Traumatology and Oncology of the Locomotor System, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland.
Piotr KrawczykDepartment of Nervous System Diseases, Orthopedics, Traumatology and Oncology of the Locomotor System, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland.
Ewelina SorokaSecond Department of Psychiatry and Psychiatric Rehabilitation, Medical University of Lublin, 1 Głuska St., 20-059 Lublin, Poland.ORCID 0000-0001-6909-2749
Małgorzata ŚmiarowskaDepartment of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Aleja Powstancόw Wlkp. 72 St., 70-111 Szczecin, Poland.
Wojciech MusiałDepartment of Nervous System Diseases, Orthopedics, Traumatology and Oncology of the Locomotor System, Collegium Medicum, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland.
Tomasz PawłowskiDivision of Psychotherapy and Psychosomatic Medicine, Wroclaw Medical University, Wyb. L. Pasteura 10 St., 50-367 Wroclaw, Poland.ORCID 0000-0002-3997-609X
Anna GrzywaczIndependent Laboratory of Health Promotion, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland.ORCID 0000-0002-2633-520X
University of Zielona Góra · PLMedical University of Lublin · PLPomeranian Medical University · PLWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere has been a noticeable and systematic growth of the use of psychoactive substances over the past few decades. Dual diagnosis is a clinical term referring to the occurrence of psychoactive substance use disorder comorbid with another psychiatric disorder in the same person. The most common type of dual diagnosis is the co-occurrence of alcohol use disorder and mood disorders in the form of a depressive episode. Co-occurrent substance use disorders are frequently influenced by genetic factors. In selecting our area of research, we focused on dopamine and the THE AIM OF THE STUDY: The aim of the study was to compare

methodsThe study group comprised 602 male volunteers: patients diagnosed with polysubstance use disorder comorbid with a depressive episode (PUD MDD) (

resultsThe patients diagnosed with PUD MDD compared to the control group of healthy volunteers showed significantly higher scores on both the STAI status and features scale and the NEO-FFI Neuroticism and Openness Scale, as well as lower scores on the Extraversion, Agreeableness, and Conscientiousness NEO-FFI scales. In the

conclusionsThe associations show that psychological factors combined with genetic data create a new area of research on addiction, including the problem of dual diagnosis. However, we want to be careful and draw no definite conclusions at this stage of our research.

Indexed as

Polymorphism, Single NucleotideAdultDepressionHumansMalePersonalityReceptors, Dopamine D4Substance-Related DisordersDRD4 protein, humanReceptors, Dopamine D4addictionDRD4 genedual diagnosis

Identifiers

PMID34828440
PMCPMC8623079
OpenAlexW3215432415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.