Evidence map›Paper›PMID 34828436›Full record

ArticleGenes2021

Genomewide Association Analyses of Lactation Persistency and Milk Production Traits in Holstein Cattle Based on Imputed Whole-Genome Sequence Data.

Victor B Pedrosa, Flavio S Schenkel, Shi-Yi Chen, Hinayah R Oliveira, Theresa M Casey, Melkaye G Melka, Luiz F Brito

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Genome-wide association study of mature cow size traits in American Angus cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
  5. Genomic Analysis of Taurine and Indicine Ancestry in the Montana Tropical Composite Population.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026
    Article
  6. Article
  7. Article
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  9. Signature of Selection Analysis Reveals Candidate Genes Related to Climate Adaptation and Production Traits in Lao Native Goats.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Genomic insights into the recent evolution and biodiversity of Italian sheep breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 4 countries.

Victor B PedrosaDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Flavio S SchenkelCentre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON N1G2W1, Canada.ORCID 0000-0001-8700-0633
Shi-Yi ChenDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Hinayah R OliveiraDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-0355-8902
Theresa M CaseyDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-8835-3550
Melkaye G MelkaDepartment of Animal and Food Science, University of Wisconsin River Falls, River Falls, WI 54022, USA.
Luiz F BritoDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-5819-0922
Purdue University West Lafayette · USUniversity of Guelph · CAUniversity of Wisconsin–River Falls · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactation persistency and milk production are among the most economically important traits in the dairy industry. In this study, we explored the association of over 6.1 million imputed whole-genome sequence variants with lactation persistency (LP), milk yield (MILK), fat yield (FAT), fat percentage (FAT%), protein yield (PROT), and protein percentage (PROT%) in North American Holstein cattle. We identified 49, 3991, 2607, 4459, 805, and 5519 SNPs significantly associated with LP, MILK, FAT, FAT%, PROT, and PROT%, respectively. Various known associations were confirmed while several novel candidate genes were also revealed, including

Indexed as

Polymorphism, Single NucleotideQuantitative Trait LociAnimalsCattleFemaleGenome-Wide Association StudyLactationdairy cattleextended lactationgenetic variantsgenomewide association studyGWASQTL

Identifiers

PMID34828436
PMCPMC8624223
OpenAlexW3216852004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.