Evidence map›Paper›PMID 34828427›Full record

ArticleGenes2021

Hemoglobin A

Noraesah Mahmud, Massimo Maffei, Massimo Mogni, Gian Luca Forni, Valeria Maria Pinto, Giuseppina Barberio, Silvana Ungari, Antonella Maffè, Cristina Curcio, Francesco Zanolli and 7 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 2 countries.

Noraesah MahmudLaboratorio Genetica Umana, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Massimo MaffeiLaboratorio Genetica Umana, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0002-2453-9065
Massimo MogniLaboratorio Genetica Umana, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.
Gian Luca ForniCentro Microcitemia e Anemie Congenite, Ospedali Galliera, 16128 Genova, Italy.
Valeria Maria PintoCentro Microcitemia e Anemie Congenite, Ospedali Galliera, 16128 Genova, Italy.ORCID 0000-0002-8375-6289
Giuseppina BarberioMedicina di Laboratorio, Azienda ULSS 2 Marca Trevigiana, 31100 Treviso, Italy.
Silvana UngariGenetica e Biologia Molecolare ASO S. Croce e Carle, 12100 Cuneo, Italy.
Antonella MaffèGenetica e Biologia Molecolare ASO S. Croce e Carle, 12100 Cuneo, Italy.
Cristina CurcioFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.ORCID 0000-0001-9275-3242
Francesco ZanolliFormerly, Servizio di Immunoematologia e Medicina Trasfusionale, A.O. Santa Maria degli Angeli, 33170 Pordenone, Italy.
Raffaella PaventaFormerly Laboratorio Analisi, ASL AT, 14100 Asti, Italy.
Mariarosa CartaMedicina di Laboratorio, Ospedale S. Bortolo, AULSS 8 Berica, 36100 Vicenza, Italy.
Alberta CaleffiU.O. Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria, 43126 Parma, Italy.
Mariella MercadantiU.O. Diagnostica Ematochimica, Azienda Ospedaliero-Universitaria, 43126 Parma, Italy.
Sauro MaoggiSebia-Italia S.r.l., 50012 Bagno a Ripoli, Italy.
Giovanni IvaldiFormerly, Laboratorio Genetica Umana, Galliera Hospital, 16128 Genova, Italy.
Domenico CovielloLaboratorio Genetica Umana, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy.ORCID 0000-0001-8440-865X
Ente Ospedaliero Ospedali Galliera · ITIstituto Giannina Gaslini · ITAzienda Sanitaria Ospedaliera S.Croce e Carle Cuneo · ITAULSS 2 Marca Trevigiana · ITAzienda Ospedaliera Santa Maria Degli Angeli · ITAzienda Sanitaria Locale di Asti · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHospital Kuala Lumpur · MYOspedale San Bortolo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemoglobin A (Hb A) (α

methodsThe most used methods for the quantification of Hb A

resultsHere, we described eight new δ-globin gene variants discovered and characterized in some laboratories in Northern Italy in recent years. These new variants were added to the many already known Hb A

conclusionsThe knowledge recognition of the delta variant on Hb analysis and accurate molecular characterization is crucial to provide an accurate definitive thalassemia diagnosis, particularly in young subjects who would like to ask for a prenatal diagnosis or preimplantation genetic diagnosis.

Indexed as

AdultAged, 80 and overbeta-ThalassemiaChilddelta-GlobinsFemaleHumansMaleMiddle AgedMutationdelta-GlobinsHb A2-variantHb-variantsβ-thalassemiaδ-globin geneδ-globin gene variant

Identifiers

PMID34828427
PMCPMC8625798
OpenAlexW3215940029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.