Evidence map›Paper›PMID 34828383›Full record

ArticleGenes2021

Propagation of a De Novo Gene under Natural Selection: Antifreeze Glycoprotein Genes and Their Evolutionary History in Codfishes.

Xuan Zhuang, C-H Christina Cheng

Abstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. DetectNAR genomics and bioinformatics · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Identifying candidatebioRxiv : the preprint server for biology · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xuan ZhuangDepartment of Biological Sciences, University of Arkansas, Fayetteville, AR 72701, USA.ORCID 0000-0002-1919-9764
C-H Christina ChengDepartment of Evolution, Ecology, and Behavior, University of Illinois, Urbana-Champaign, IL 61801, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The de novo birth of functional genes from non-coding DNA as an important contributor to new gene formation is increasingly supported by evidence from diverse eukaryotic lineages. However, many uncertainties remain, including how the incipient de novo genes would continue to evolve and the molecular mechanisms underlying their evolutionary trajectory. Here we address these questions by investigating evolutionary history of the de novo antifreeze glycoprotein (AFGP) gene and gene family in gadid (codfish) lineages. We examined AFGP phenotype on a phylogenetic framework encompassing a broad sampling of gadids from freezing and non-freezing habitats. In three select species representing different AFGP-bearing clades, we analyzed all AFGP gene family members and the broader scale

Indexed as

AnimalsAntifreeze ProteinsCloning, MolecularCodon UsageEvolution, MolecularFishesFish ProteinsMultigene FamilyPhylogenySelection, GeneticSequence Analysis, DNAAntifreeze ProteinsFish Proteinsantifreeze glycoproteinde novo geneevolutionary processgadidgene family expansionmolecular mechanismnew gene evolutionrepetitive protein

Identifiers

PMID34828383
PMCPMC8622921

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.