Evidence map›Paper›PMID 34828284›Full record

ArticleGenes2021

Associations of Polymorphisms Localized in the 3'UTR Regions of the

Ruta Insodaite, Alina Smalinskiene, Vykintas Liutkevicius, Virgilijus Ulozas, Roberta Poceviciute, Arunas Bielevicius, Laimutis Kucinskas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Genetic alterations ofOpen life sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ruta InsodaiteInstitute of Biology Systems and Genetic Research, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania.
Alina SmalinskieneInstitute of Biology Systems and Genetic Research, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania.
Vykintas LiutkeviciusDepartment of Otorhinolaryngology, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.
Virgilijus UlozasDepartment of Otorhinolaryngology, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.
Roberta PoceviciuteInstitute of Biology Systems and Genetic Research, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania.
Arunas BieleviciusInstitute of Biology Systems and Genetic Research, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania.
Laimutis KucinskasInstitute of Biology Systems and Genetic Research, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania.
Lithuanian University of Health Sciences · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic variations, localized in the 3' untranslated region (UTR) in mitogen-activated protein kinase (MAPK) pathway-related genes, may alter the transcription and impact the pathogenesis of laryngeal squamous cell carcinoma (LSCC). The present study investigated the associations of single-nucleotide polymorphisms (SNP), localized in the 3'UTR) of the

methodsGenomic DNA and clinical data were collected from 327 adult men with LSCC. The control group was formed from 333 healthy men. Genotyping of the SNPs was performed using TaqMan SNP genotyping assays. Five

resultsSignificant associations of the studied SNPs with reduced LSCC risk were observed between

conclusionsAccording to the present study, 3'UTR SNP in the

Indexed as

Polymorphism, Single Nucleotide3' Untranslated RegionsAgedCase-Control StudiesGenetic Association StudiesGenetic Predisposition to DiseaseGTP PhosphohydrolasesHumansLaryngeal NeoplasmsLithuaniaLymphatic MetastasisMaleMembrane ProteinsMiddle AgedMitogen-Activated Protein Kinase 1Neoplasm Staging3' Untranslated RegionsGTP PhosphohydrolasesKRAS protein, humanMAPK1 protein, humanMembrane ProteinsMitogen-Activated Protein Kinase 1NRAS protein, humanProto-Oncogene Proteins p21(ras)KRASlaryngeal squamous cell carcinomaMAPK1mitogen-activated protein kinasesNRASsingle-nucleotide polymorphisms

Identifiers

PMID34828284
PMCPMC8625477
OpenAlexW3208429307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.