Evidence map›Paper›PMID 34828256›Full record

ArticleGenes2021

Impact of Bicarbonate-β-Lactam Exposures on Methicillin-Resistant

Selvi C Ersoy, Blake M Hanson, Richard A Proctor, Cesar A Arias, Truc T Tran, Henry F Chambers, Arnold S Bayer

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 12 citations in OpenAlex.

  1. Genomic investigation and clinical correlates of theAntimicrobial agents and chemotherapy · 2024
    Trial
  2. An Achilles' heel for methicillin-resistantAntimicrobial agents and chemotherapy · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Sensitizing methicillin-resistantAntimicrobial agents and chemotherapy · 2024
    Article
  9. Measuring beta-lactam minimum inhibitory concentrations inJournal of clinical microbiology · 2024
    Review
  10. Role of the NaHCOMicrobiology spectrum · 2023
    Article
  11. Article
  12. The NaHCOAntimicrobial agents and chemotherapy · 2022
    Article
  13. Impacts of NaHCOAntibiotics (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Selvi C ErsoyThe Lundquist Institute, Torrance, CA 90502, USA.ORCID 0000-0002-8792-2061
Blake M HansonCenter for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA.
Richard A ProctorSchool of Medicine and Public Health, University of Wisconsin, Madison, WI 53706-152, USA.ORCID 0000-0003-3011-7958
Cesar A AriasCenter for Infectious Diseases, School of Public Health, University of Texas Health Science Center, Houston, TX 77030, USA.
Truc T TranCenter for Antimicrobial Resistance and Microbial Genomics, Division of Infectious Diseases, University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030, USA.
Henry F ChambersUCSF School of Medicine, San Francisco, CA 94143, USA.
Arnold S BayerThe Lundquist Institute, Torrance, CA 90502, USA.ORCID 0000-0003-1968-0192
Methodist Hospital · USThe University of Texas Health Science Center at Houston · USUniversity of California, Los Angeles · USUniversity of Wisconsin–Madison · US

Funding

Project 3: Functional Microbiome and Host Signatures in Transition from Commensal to pathogenP01AI152999 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SAVIDGE, TOR C. · 2020 to 2025
$12.0M
VENOUS: A translational study of enterococcal bacteremiaR01AI148342 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2020 to 2024
$3.9M
The LiaFSR system and antimicrobial peptide resistance in enterococciR01AI134637 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Cesar Augusto Arias · 2018 to 2026
$3.7M
Molecular Mechanisms Of Daptomycin Resistance In EnterococciR01AI093749 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2011 to 2015
$1.9M
Bicarbonate-Mediated Enhancement of Beta-Lactam-MRSA Killing: Mechanisms and Clinical TranslatabilityR01AI146078 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI XIONG, YAN Q. · 2019 to 2023
$1.9M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Mobile Genetic Elements and Clinical Outcomes in Staphylococcus aureus BacteremiaK01AI148593 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HANSON, BLAKE M · 2020 to 2023
$519k
NIAID NIH HHS K01 AI148593NIAID NIH HHS K24 AI121296NIAID NIH HHS P01 AI152999NIAID NIH HHS R01 AI093749NIAID NIH HHS R01 AI134637NIAID NIH HHS R01 AI146078NIAID NIH HHS R01 AI148342
6 · The paper itself

Abstract

Methicillin-resistant

Indexed as

Drug Resistance, Multiple, BacterialMethicillin-Resistant Staphylococcus aureusBacterial ProteinsBacterial Typing Techniquesbeta-Lactam Resistancebeta-LactamsBicarbonatesGene Expression Regulation, BacterialHumansMicrobial Sensitivity TestsRegulonRNA-SeqBacterial Proteinsbeta-LactamsBicarbonatesMethicillin-resistant Staphylococcus aureus (MRSA)RNA-sequencing (RNA-seq)sodium bicarbonate (NaHCO3)β-lactam susceptibility

Identifiers

PMID34828256
PMCPMC8619011
OpenAlexW3205706868

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.