ReviewAnimals : an open access journal from MDPI2021
Efficacy and Safety of Dexmedetomidine Premedication in Balanced Anesthesia: A Systematic Review and Meta-Analysis in Dogs.
Review in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Anaesthetic Management Including Low-Dose Dexmedetomidine and Butorphanol in Dogs Undergoing ECG-Gated Cardiac Computed Tomography: A Retrospective Case Series.Veterinary sciences · 2026Article
- Interfascial Plane Blocks for Perioperative Analgesia in Dogs Undergoing Laparoscopic Ovariectomy: A Retrospective Study (2020-2025).Animals : an open access journal from MDPI · 2026Article
- Timing-controlled concept for extubation in brachycephalic dogs: α2-bridged on-demand extubation.Frontiers in veterinary science · 2026Review
- Short communication: Pharmacological semen collection in dogs via urethral catheterization: evaluation of cardiorespiratory stability and semen quality under continuous dexmedetomidine infusion.Veterinary research communications · 2025Article
- Dexmedetomidine or Butorphanol for Co-Induction of General Anaesthesia with Propofol in Unpremedicated Healthy Dogs: Clinical and Echocardiographic Assessment.Veterinary sciences · 2025Article
- Comparison of Dexmedetomidine/Morphine and Xylazine/Morphine as Premedication in Isoflurane-Anesthetized Sheep.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- Machine learning analysis of factors contributing to hypotension after lumbosacral epidural anaesthesia in dogs undergoing abdominal surgery.Scientific reports · 2025Article
- Clinical Comparison of Ketamine-Dexmedetomidine With Ketamine-Propofol During Canine Orchiectomy: A Randomized Study.Veterinary medicine and science · 2025Article
- Tiletamine/Zolazepam and Ketamine with Dexmedetomidine (TKD) Cocktail Is as Effective as Tiletamine/Zolazepam and Ketamine with Xylazine (TKX) in Providing Pig General Anesthesia.Animals : an open access journal from MDPI · 2024Article
- Clinical Effects and Pharmacokinetic Profile of Intramuscular Dexmedetomidine (10 μg/kg) in Cats.Animals : an open access journal from MDPI · 2024Article
- Effect of dexmedetomidine constant rate infusion on the analgesic duration of peripheral nerve blocks in dogs: a randomized clinical study.Scientific reports · 2024Article
- Anesthetic management of a dog undergoing unilateral adrenalectomy for phaeochromocytoma excision using a partial intravenous anesthetic protocol.Open veterinary journal · 2024Article
- Evaluation of the Quality of Recovery from General Anesthesia in Dogs with Two Different Low Doses of Dexmedetomidine.Animals : an open access journal from MDPI · 2024Article
- Repeated Administration of the Cannabinoid WIN Alters the Isoflurane-Sparing Effect of Morphine and Dexmedetomidine.Veterinary sciences · 2023Article
- Laparoscopic ureteroneocystostomy in the treatment of urinary incontinence due to ectopy of the ureters in female dogs: A pilot study.PloS one · 2023Article
- Use of a novel shockwave trode results in better patient acceptance in awake canine patients treated for musculoskeletal disease.Frontiers in veterinary science · 2023Article
- Multiple uses of dexmedetomidine in small animals: a mini review.Frontiers in veterinary science · 2023Review
- Dexmedetomidine Effectively Sedates Asian Elephants (Animals : an open access journal from MDPI · 2022Article
- Adoption of Dexmedetomidine in Different Doses at Different Timing in Perioperative Patients.BioMed research international · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dexmedetomidine is commonly used in small animal anesthesia for its potent sedative and analgesic properties; however, concerns regarding its cardiovascular effects prevent its full adoption into veterinary clinical practice. This meta-analysis was to determine the effects of dexmedetomidine on sedation, analgesia, cardiovascular and adverse reactions in dogs compared to other premedications. Following the study protocol based on the Cochrane Review Methods, thirteen studies were included in this meta-analysis ultimately, involving a total of 576 dogs. Dexmedetomidine administration probably improved in sedation and analgesia in comparison to acepromazine, ketamine and lidocaine (MD: 1.96, 95% CI: [-0.08, 4.00],
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.