Evidence map›Paper›PMID 34827794›Full record

ArticleAnimals : an open access journal from MDPI2021

Interleukin 17D Enhances the Developmental Competence of Cloned Pig Embryos by Inhibiting Apoptosis and Promoting Embryonic Genome Activation.

Xiao Wu, Huaxing Zhao, Junkun Lai, Ning Zhang, Junsong Shi, Rong Zhou, Qiaoyun Su, Enqin Zheng, Zheng Xu, Sixiu Huang and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Exposure ofFrontiers in veterinary science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Xiao WuNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Huaxing ZhaoNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Junkun LaiNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Ning ZhangNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Junsong ShiGuangdong Wens Pig Breeding Technology Co., Ltd., Yunfu 527499, China.
Rong ZhouGuangdong Wens Pig Breeding Technology Co., Ltd., Yunfu 527499, China.
Qiaoyun SuGuangdong Wens Pig Breeding Technology Co., Ltd., Yunfu 527499, China.
Enqin ZhengNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Zheng XuNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Sixiu HuangNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Linjun HongNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-6554-7918
Ting GuNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-8732-7377
Jie YangNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-7031-2160
Huaqiang YangNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.ORCID 0000-0002-4287-0026
Gengyuan CaiNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Zhenfang WuNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
Zicong LiNational Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China.
South China Agricultural University · CNWen's Food Group (China) · CN

Funding

Department of Science and Technology of Guangdong Province, China 2019B1515210027Department of Science and Technology of Guangdong Province, China 2019BT02N630National Natural Science Foundation of China 31772554
6 · The paper itself

Abstract

Cloned animals generated by the somatic cell nuclear transfer (SCNT) approach are valuable for the farm animal industry and biomedical science. Nevertheless, the extremely low developmental efficiency of cloned embryos hinders the application of SCNT. Low developmental competence is related to the higher apoptosis level in cloned embryos than in fertilization-derived counterparts. Interleukin 17D (IL17D) expression is up-regulated during early mouse embryo development and is required for normal development of mouse embryos by inhibiting apoptosis. This study aimed to investigate whether IL17D plays roles in regulating pig SCNT embryo development. Supplementation of IL17D to culture medium improved the developmental competence and decreased the cell apoptosis level in cloned porcine embryos. The transcriptome data indicated that IL17D activated apoptosis-associated pathways and promoted global gene expression at embryonic genome activation (EGA) stage in treated pig SCNT embryos. Treating pig SCNT embryos with IL17D up-regulated expression of

Indexed as

apoptosisEGAIL17DporcineSCNT

Identifiers

PMID34827794
PMCPMC8614321
OpenAlexW3209596833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.