Evidence map›Paper›PMID 34827724›Full record

ArticleBiomolecules2021

Dynamic DNA Methylation Changes in the

Ariane Wiegand, Arne Blickle, Christof Brückmann, Simone Weller, Vanessa Nieratschker, Christian Plewnia

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. International journal of molecular sciences · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Personality andFrontiers in genetics · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ariane WiegandTübingen Center for Mental Health, Department of Psychiatry and Psychotherapy, Molecular Psychiatry, University Hospital Tübingen, Calwerstraße 14, 72076 Tübingen, Germany.
Arne BlickleTübingen Center for Mental Health, Department of Psychiatry and Psychotherapy, Molecular Psychiatry, University Hospital Tübingen, Calwerstraße 14, 72076 Tübingen, Germany.
Christof BrückmannTübingen Center for Mental Health, Department of Psychiatry and Psychotherapy, Molecular Psychiatry, University Hospital Tübingen, Calwerstraße 14, 72076 Tübingen, Germany.
Simone WellerTübingen Center for Mental Health, Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University Hospital Tübingen, Calwerstraße 14, 72076 Tübingen, Germany.ORCID 0000-0002-5348-6513
Vanessa NieratschkerTübingen Center for Mental Health, Department of Psychiatry and Psychotherapy, Molecular Psychiatry, University Hospital Tübingen, Calwerstraße 14, 72076 Tübingen, Germany.
Christian PlewniaTübingen Center for Mental Health, Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University Hospital Tübingen, Calwerstraße 14, 72076 Tübingen, Germany.
University Children's Hospital Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in epigenetic modifications present a mechanism how environmental factors, such as the experience of stress, can alter gene regulation. While stress-related disorders have consistently been associated with differential DNA methylation, little is known about the time scale in which these alterations emerge. We investigated dynamic DNA methylation changes in whole blood of 42 healthy male individuals in response to a stressful cognitive task, its association with concentration changes in cortisol, and its modulation by transcranial direct current stimulation (tDCS). We observed a continuous increase in

Indexed as

Catechol O-MethyltransferaseDNA MethylationPromoter Regions, GeneticStress, PsychologicalTranscranial Direct Current StimulationAdultEpigenesis, GeneticHumansHydrocortisoneMaleSalivaYoung AdultCatechol O-MethyltransferaseCOMT protein, humanHydrocortisoneCOMTDNA methylationepigeneticsstress responsetranscranial direct current stimulation

Identifiers

PMID34827724
PMCPMC8615564
OpenAlexW3216145433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.