Evidence map›Paper›PMID 34827661›Full record

ArticleBiomolecules2021

Genetic and Metabolic Determinants of Atrial Fibrillation in a General Population Sample: The CHRIS Study.

David B Emmert, Vladimir Vukovic, Nikola Dordevic, Christian X Weichenberger, Chiara Losi, Yuri D'Elia, Claudia Volpato, Vinicius V Hernandes, Martin Gögele, Luisa Foco and 10 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Clinical and Metabolic Signatures ofKidney international reports · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Genetics, transcriptomics, metagenomics, and metabolomics in the pathogenesis and prediction of atrial fibrillation.European heart journal supplements : journal of the European Society of Cardiology · 2024
    Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 3 countries.

David B EmmertEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Vladimir VukovicEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.ORCID 0000-0002-9561-7825
Nikola DordevicEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Christian X WeichenbergerEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Chiara LosiDepartment of Cardiology, Tappeiner F. Merano Hospital, 39012 Merano, Italy.
Yuri D'EliaEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Claudia VolpatoEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Vinicius V HernandesEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Martin GögeleEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.ORCID 0000-0003-4785-4348
Luisa FocoEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Giulia PontaliEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.ORCID 0000-0002-4521-8981
Deborah MascalzoniEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Francisco S DominguesEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Rupert PaulmichlDepartment of Cardiology, Tappeiner F. Merano Hospital, 39012 Merano, Italy.
Peter P PramstallerEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Cristian PattaroEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Alessandra RossiniEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.ORCID 0000-0002-0440-1130
Johannes RainerEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.ORCID 0000-0002-6977-7147
Christian FuchsbergerEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.
Marzia De BortoliEurac Research, Institute for Biomedicine (Affiliated to the University of Lübeck), 39100 Bolzano, Italy.ORCID 0000-0002-1348-1304
Eurac Research · ITKrankenhaus Meran · ITUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is a supraventricular arrhythmia deriving from uncoordinated electrical activation with considerable associated morbidity and mortality. To expand the limited understanding of AF biological mechanisms, we performed two screenings, investigating the genetic and metabolic determinants of AF in the Cooperative Health Research in South Tyrol study. We found 110 AF cases out of 10,509 general population individuals. A genome-wide association scan (GWAS) identified two novel loci (

Indexed as

Atrial FibrillationGenome-Wide Association StudyPolymorphism, Single NucleotideAdultAgedAllelesCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansLysophosphatidylcholinesMaleMiddle AgedLysophosphatidylcholinesatrial fibrillationCooperative Health Research in South Tyrolfamilial aggregationGWASmetabolomicsrare alleles

Identifiers

PMID34827661
PMCPMC8615508
OpenAlexW3214316807

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.