Evidence map›Paper›PMID 34827558›Full record

ArticleBiomolecules2021

Altered

Aiying Yu, Jingfu Zhao, Jieqiang Zhong, Junyao Wang, Shiv Pratap S Yadav, Bruce A Molitoris, Mark C Wagner, Yehia Mechref

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Glycosylation in kidney diseases.Precision clinical medicine · 2025
    Review
  3. Article
  4. Review
  5. An Efficient and EconomicalMetabolites · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aiying YuDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-3323-8184
Jingfu ZhaoDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Jieqiang ZhongDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Junyao WangDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-7614-5615
Shiv Pratap S YadavDepartment of Medicine, Nephrology Division, Indiana University, Indianapolis, IN 46202, USA.
Bruce A MolitorisDepartment of Medicine, Nephrology Division, Indiana University, Indianapolis, IN 46202, USA.
Mark C WagnerDepartment of Medicine, Nephrology Division, Indiana University, Indianapolis, IN 46202, USA.
Yehia MechrefDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-6661-6073
Texas Tech University · USIndiana University – Purdue University Indianapolis · US

Funding

NIH HHS 1R01DK091623-06NIH HHS 1R01GM112490NIH HHS 1R01GM130091NIH HHS P30DK079312-13
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is defined as a decrease in renal function or glomerular filtration rate (GFR), and proteinuria is often present. Proteinuria increases with age and can be caused by glomerular and/or proximal tubule (PT) alterations. PT cells have an apical brush border membrane (BBM), which is a highly dynamic, organized, and specialized membrane region containing multiple glycoproteins required for its functions including regulating uptake, secretion, and signaling dependent upon the physiologic state. PT disorders contribute to the dysfunction observed in CKD. Many glycoprotein functions have been attributed to their

Indexed as

MicrovilliPolysaccharidesRenal Insufficiency, ChronicAnimalsChromatography, LiquidDisease Models, AnimalGlycomicsGlycosylationMaleProteinuriaRatsRats, Sprague-DawleyTandem Mass SpectrometryPolysaccharidesbrush-border membranechronic kidney diseasedifferential expression analysisLC–MS/MSobese and diabeticO-glycanproteinuria and hypertension

Identifiers

PMID34827558
PMCPMC8615448
OpenAlexW3206243439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.