Evidence map›Paper›PMID 34827494›Full record

ArticleBrain sciences2021

The Efficacy of Interlimb-Coordinated Intervention on Gait and Motor Function Recovery in Patients with Acute Stroke: A Multi-Center Randomized Controlled Trial Study Protocol.

Wai-Leung Ambrose Lo, Dandan Chen, Jiangli Zhao, Yan Leng, Ruihao Bian, Wenzhu Huang, Yahui Liang, Yu-Rong Mao, Dong-Feng Huang

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wai-Leung Ambrose LoGuangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China.
Dandan ChenGuangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China.
Jiangli ZhaoGuangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China.
Yan LengGuangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0002-0310-3350
Ruihao BianGuangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China.
Wenzhu HuangDepartment of Rehabilitation Medicine, The Fifth People's Hospital of Foshan, Foshan 528211, China.
Yahui LiangDepartment of Traditional Chinese Medicine, Beijing Rehabilitation Hospital of Capital Medical University, Beijing 100144, China.
Yu-Rong MaoGuangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China.
Dong-Feng HuangGuangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, Sun Yat-sen University, Guangzhou 510080, China.
Sun Yat-sen University · CNCapital Medical University · CNFoshan Second People's Hospital · CN

Funding

5010 Planning Project of Sun Yat-Sen University of China 2014001National Key Research and Development Program of China 2020YFC2004300National Key Research and Development Program of China 2020YFC2004304National Natural Science Foundation of China 81971224
6 · The paper itself

Abstract

backgroundThe efficacy of interlimb-coordinated training on gait and upper limb functional improvement remains unclear. The latest published randomized controlled trials have supported the potential benefits of interlimb-coordinated training to enhance gait function. Upper limb functional recovery may also benefit from interlimb-coordinated training since most everyday activities require the coordinated use of both hands to complete a task. This study investigates the efficacy of interlimb-coordinated training on gait and upper limb functional recovery over a short-medium term period.

methodsA total of 226 acute stroke patients will be recruited from four centres over four years. Patients will be randomly allocated to either conventional therapy or conventional therapy plus interlimb-coordinated training. Outcomes will be recorded at baseline, after 2 weeks of intervention, and at 3- and 6-months post-intervention. Gait speed is the primary outcome measure. Secondary outcome measures include Fugl-Meyer Assessment of Motor Recovery, Berg Balance Scale, Timed Up and Go test, Action Research Arm Test, electroencephalography, and magnetic resonance imaging.

conclusionThe results of this trial will provide an in-depth understanding of the efficacy of early interlimb-coordinated intervention on gait and upper functional rehabilitation and how it may relate to the neural plasticity process.

Indexed as

arm cyclingEEGgaitinterlimb coordinatedlimb linkageMRIstroke

Identifiers

PMID34827494
PMCPMC8615375
OpenAlexW3211876431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.