Evidence map›Paper›PMID 34827450›Full record

ArticleBrain sciences2021

Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study.

Shuo Xu, Qing Yang, Mengye Chen, Panmo Deng, Ren Zhuang, Zengchun Sun, Chong Li, Zhijie Yan, Yongli Zhang, Jie Jia

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Effectiveness of intermittent theta burst stimulation (iTBS) on Post-Stroke motor dysfunction: A Meta-Analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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  6. Article
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  9. Targeted neurorehabilitation strategies in post-stroke aphasia.Restorative neurology and neuroscience · 2023
    Review
  10. Article
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  12. Article
  13. Review
  14. Efficacy of rTMS in Post-Stroke Bilingual Aphasia: A Single Case Experimental Design.International journal of language & communication disorders
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Shuo XuDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-9347-0882
Qing YangDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Mengye ChenDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Panmo DengDepartment of Rehabilitation Medicine, Jingan District Central Hospital Affiliated to Fudan University, Shanghai 200040, China.
Ren ZhuangDepartment of Rehabilitation Medicine, Changzhou Dean Hospital, Changzhou 213000, China.
Zengchun SunSichuan Bayi Rehabilitation Center, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of TCM, Chengdu 610075, China.
Chong LiFaculty of Sport and Science, Shanghai University of Sport, Shanghai 200040, China.
Zhijie YanThe Third Affiliated Hospital, Xinxiang Medical University, Xinxiang 453003, China.
Yongli ZhangInstitute of Rehabilitation, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Jie JiaDepartment of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China.
Fudan University · CNFujian University of Traditional Chinese Medicine · CNSecond Affiliated Hospital of Chengdu University of Traditional Chinese · CNShanghai University of Sport · CNXinxiang Medical University · CN

Funding

the National Key Research & Development Program of the Ministry of Science and Technology of the People's Republic of China; the National Natural Science Foundation of China; the Innovative Research Group Project of National Natural Science Foundation of 2018YFC2002300; 9194830003; 82021002
6 · The paper itself

Abstract

Intermittent theta-burst stimulation (iTBS) is a high-efficiency transcranial magnetic stimulation (TMS) paradigm that has been applied to post-stroke aphasia (PSA). However, its efficacy mechanisms have not been clarified. This study aimed to explore the immediate effects of iTBS of the primary motor cortex (M1) of the affected hemisphere, on the functional activities and connectivity of the brains of PSA patients. A total of 16 patients with aphasia after stroke received iTBS with 800 pulses for 300 s. All patients underwent motor, language, and cognitive assessments and resting-state functional MRI scans immediately before and after the iTBS intervention. Regional, seed-based connectivity, and graph-based measures were used to test the immediate functional effects of the iTBS intervention, including the fractional amplitude of low-frequency fluctuation (fALFF), degree centrality (DC), and functional connectivity (FC) of the left M1 area throughout the whole brain. The results showed that after one session of iTBS intervention, the fALFF, DC, and FC values changed significantly in the patients' brains. Specifically, the DC values were significantly higher in the right middle frontal gyrus and parts of the left parietal lobe (

Indexed as

aphasiafMRIiTBSneuroplasticityrehabilitationstroke

Identifiers

PMID34827450
PMCPMC8615629
OpenAlexW3208599320

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.