Evidence map›Paper›PMID 34827430›Full record

ArticleBrain sciences2021

Electromagnetic Field Stimulation Attenuates Phasic Nociception after Complete Spinal Cord Injury in Rats.

Suneel Kumar, Ajay Pal, Suman Jain, Thirumurthy Velpandian, Rashmi Mathur

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Suneel KumarDepartment of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.ORCID 0000-0003-4829-8654
Ajay PalDepartment of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.ORCID 0000-0002-4615-9282
Suman JainDepartment of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
Thirumurthy VelpandianDepartment of Ocular Pharmacy and Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India.
Rashmi MathurDepartment of Physiology, All India Institute of Medical Sciences, New Delhi 110029, India.
All India Institute of Medical Sciences · IN

Funding

Department of Science and Technology ILTP-A-9.21
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) is one of the most incapacitating pathologies, leading to huge rehabilitation challenges besides a social-economic burden on SCI patients and their families. There is no complete curative treatment available so far. Non-invasive and patient-friendly use of extremely low-frequency electromagnetic field stimulation (EMF) has emerged as a therapeutic and rehabilitation option. In this study, we tested whole-body EMF stimulation on thoracic complete SCI-induced nociception including sensorimotor deficits in rats. The EMF application significantly attenuated hyperalgesia and allodynia to thermal, electrical, and chemical stimuli from 6 weeks onwards as well as restoration of spinal reflexes, viz., H-reflex and nociceptive flexion reflex at the study endpoint (week 8). Besides, massively increased glutamate at the SCI injury site was observed in SCI rats with no treatment, which was also attenuated significantly by EMF stimulation. Spinal cord histology of the injury area showed a decrease in lesion volume and glial population in the EMF-stimulated rats. These findings indicate the beneficial role of EMF stimulation after thoracic complete SCI in adult male rats and, thereby, a beneficial patient-friendly rehabilitation tool.

Indexed as

complete spinal cord injuryelectromagnetic stimulationglial cellsglutamateH-reflexhyperalgesia and allodynianeurotransmitternociceptive flexion reflex

Identifiers

PMID34827430
PMCPMC8615391
OpenAlexW3209475972

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.