ArticleBrain sciences2021
Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.
Atiqul Haq Mazumder, Jennifer Barnett, Erkki Tapio Isometsä, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Ari Ahola-Olli, Jarmo Hietala and 19 more
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In one paragraphArticle in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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29 authors.
Atiqul Haq MazumderDepartment of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland.ORCID 0000-0002-2148-4070 Jennifer BarnettCambridge Cognition, University of Cambridge, Cambridge CB25 9TU, UK.
Erkki Tapio IsometsäDepartment of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.ORCID 0000-0001-5956-2399 Nina LindbergDepartment of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.
Minna Torniainen-HolmMental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland.ORCID 0000-0003-2149-855X Markku LähteenvuoDepartment of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland.ORCID 0000-0002-7244-145X Kaisla LahdensuoInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
Martta KerkeläDepartment of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland.ORCID 0000-0002-1181-2632 Ari Ahola-OlliInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-4451-3487 Tuula KieseppäDepartment of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.
Tuomas JukuriDepartment of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland.
Katja HäkkinenDepartment of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland.ORCID 0000-0001-8222-7505 Erik CederlöfMental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland.
Willehard HaakiInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-2850-7650 Risto KajanneInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-3405-7115 Asko WegeliusDepartment of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.
Teemu MännynsaloInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
Jussi Niemi-PynttäriInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.
Kimmo SuokasInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0001-6296-6343 Jouko LönnqvistMental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland.
Jari TiihonenDepartment of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, 70240 Kuopio, Finland.ORCID 0000-0002-0400-6798 Tiina PaunioDepartment of Psychiatry, University Hospital and University of Helsinki, 00029 Helsinki, Finland.ORCID 0000-0002-5560-0666 Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0002-2527-5874 Jaana SuvisaariMental Health Unit, Finnish Institute for Health and Welfare (THL), 00271 Helsinki, Finland.ORCID 0000-0001-7167-0990 Juha VeijolaDepartment of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, 90014 Oulu, Finland.ORCID 0000-0002-4139-9981 Funding
The H2020 Marie Skłodowska-Curie Actions co-funding of regional, national, and international pro-grams (COFUND) 713606The Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA 6045290-5500000710 and 6000009-5500000710The the Iso-Mällisen Foundation (Iso-Mällisen Säätiö) 0400 584622
6 · The paper itselfAbstract
The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.
Indexed as
bipolar disordercognitionhazardous drinkingPGSreaction timeschizoaffective disorderschizophreniavisual memory
Identifiers
PMID34827421
PMCPMC8615595
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