Evidence map›Paper›PMID 34827409›Full record

ArticleBrain sciences2021

Associations of Immune Genetic Variability with Gulf War Illness in 1990-1991 Gulf War Veterans from the Gulf War Illness Consortium (GWIC) Multisite Case-Control Study.

Janet K Coller, Jonathan Tuke, Taylor J Wain, Emily Quinn, Lea Steele, Maria Abreu, Kristina Aenlle, Nancy Klimas, Kimberly Sullivan

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Janet K CollerDiscipline of Pharmacology, School of Biomedicine, University of Adelaide, Adelaide 5005, South Australia, Australia.ORCID 0000-0002-8273-5048
Jonathan TukeSchool of Mathematical Sciences, University of Adelaide, Adelaide 5005, South Australia, Australia.ORCID 0000-0002-1688-8951
Taylor J WainDiscipline of Pharmacology, School of Biomedicine, University of Adelaide, Adelaide 5005, South Australia, Australia.
Emily QuinnBiostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA 02118, USA.
Lea SteeleVeterans Health Research Program, Beth K. and Stuart C. Yudofsky Division of Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA.
Maria AbreuInstitute for Neuroimmune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.
Kristina AenlleInstitute for Neuroimmune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.
Nancy KlimasInstitute for Neuroimmune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.
Kimberly SullivanDepartment of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.ORCID 0000-0001-7940-6123
Nova Southeastern University · USThe University of Adelaide · AUBoston University · USBaylor College of Medicine · US

Funding

Congressionally Directed Medical Research Programs W81XWH-13-2-0072
6 · The paper itself

Abstract

Gulf War illness (GWI) encompasses a constellation of persistent debilitating symptoms associated with significant changes in central nervous system (CNS) and immune functioning. Currently, there is no validated biomarker for GWI risk susceptibility. Given the impact of immune responses linked to GWI symptomology, genetic variability that causes persistent inflammatory/immune alterations may be key. This Boston University-based Gulf War Illness Consortium (GWIC) study investigated the impact of single nucleotide polymorphisms (SNPs) in variants of immune and pain genetic markers

Indexed as

Gulf War illnessimmune geneticsobjective biomarkerpredictive genetic modeltoll-like receptor 4

Identifiers

PMID34827409
PMCPMC8615505
OpenAlexW3207978381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.