Evidence map›Paper›PMID 34827404›Full record

ArticleBrain sciences2021

African Gene Flow Reduces Beta-Ionone Anosmia/Hyposmia Prevalence in Admixed Malagasy Populations.

Harilanto Razafindrazaka, Veronica Pereda-Loth, Camille Ferdenzi, Margit Heiske, Omar Alva, Minah Randriamialisoa, Caroline Costedoat, Michel Signoli, Thierry Talou, Monique Courtade-Saidi and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Harilanto RazafindrazakaAix Marseille University, CNRS, EFS, ADES, 13344 Marseille, France.ORCID 0000-0001-5209-4780
Veronica Pereda-LothEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, France.
Camille FerdenziCNRS, UMR5292, Lyon Neuroscience Research Center, University Lyon, 69000 Lyon, France.ORCID 0000-0001-5572-0361
Margit HeiskeEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, France.
Omar AlvaEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, France.
Minah RandriamialisoaDépartement Histoire, Faculté des Lettres et des Sciences Humaines, Université d'Antananarivo, Antananarivo 101, Madagascar.
Caroline CostedoatAix Marseille University, CNRS, EFS, ADES, 13344 Marseille, France.ORCID 0000-0002-1848-6366
Michel SignoliAix Marseille University, CNRS, EFS, ADES, 13344 Marseille, France.
Thierry TalouLaboratoire de Chimie Agro-Industrielle, Université de Toulouse, INP-ENSIACET, 31030 Toulouse, France.
Monique Courtade-SaidiLaboratoire d'Histologie-Embryologie, Faculté de Médecine Rangueil, 31062 Toulouse, France.ORCID 0000-0002-0884-4131
Anne BolandCentre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, 91057 Evry, France.ORCID 0000-0001-8789-5676
Jean-François DeleuzeCentre National de Recherche en Génomique Humaine (CNRGH), Institut de Biologie François Jacob, CEA, 91057 Evry, France.
Catherine RoubyCNRS, UMR5292, Lyon Neuroscience Research Center, University Lyon, 69000 Lyon, France.
Chantal RadimilahyInstitut de Civilisations/Musée d'Art et d'Archéologie, Université d'Antananarivo, Isoraka, Antananarivo 101, Madagascar.
Thierry LetellierEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, France.
Moustafa BensafiCNRS, UMR5292, Lyon Neuroscience Research Center, University Lyon, 69000 Lyon, France.
Denis PierronEquipe de Médecine Evolutive, URU EVOLSAN, Faculté de Chirurgie Dentaire, Université de Toulouse III, 31073 Toulouse, France.
Université Toulouse III - Paul Sabatier · FRCentre National de la Recherche Scientifique · FRUniversité Claude Bernard Lyon 1 · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRUniversity of Antananarivo · MGHôpital Rangueil · FRUniversité Fédérale de Toulouse Midi-Pyrénées · FR

Funding

Agence Nationale de la Recherche ANR-12-PDOC-0037-01Agence Nationale de la Recherche ANR Labex IASTCentre National de la Recherche Scientifique ExtremoConseil National de la Recherche Scientifique IEA - International Emerging Actions 2020Fondation Aix-Marseille Universite Amidex - Pépinière D'excellenceFondation Nestlé 2015
6 · The paper itself

Abstract

While recent advances in genetics make it possible to follow the genetic exchanges between populations and their phenotypic consequences, the impact of the genetic exchanges on the sensory perception of populations has yet to be explored. From this perspective, the present study investigated the consequences of African gene flow on odor perception in a Malagasy population with a predominantly East Asian genetic background. To this end, we combined psychophysical tests with genotype data of 235 individuals who were asked to smell the odorant molecule beta-ionone (βI). Results showed that in this population the ancestry of the OR5A1 gene significantly influences the ability to detect βI. At the individual level, African ancestry significantly protects against specific anosmia/hyposmia due to the higher frequency of the functional gene (OR ratios = 14, CI: 1.8-110,

Indexed as

admixturebeta-iononeMadagascarolfactionspecific anosmia

Identifiers

PMID34827404
PMCPMC8615941
OpenAlexW3209516243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.