Evidence map›Paper›PMID 34827352›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock.

Osamu Nomura, Takateru Ihara, Yoshihiko Morikawa, Hiroshi Sakakibara, Yuho Horikoshi, Nobuaki Inoue

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Osamu NomuraDepartment of Emergency and Disaster Medicine, Hirosaki University, Hirosaki 036-8562, Japan.ORCID 0000-0003-1296-1768
Takateru IharaDivision of Pediatric Emergency Medicine, Tokyo Metropolitan Children's Medical Center, Tokyo 183-8561, Japan.
Yoshihiko MorikawaClinical Research Support Center, Tokyo Metropolitan Children's Medical Center, Tokyo 183-8561, Japan.ORCID 0000-0002-1437-0374
Hiroshi SakakibaraDivision of General Pediatrics, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo 183-8561, Japan.
Yuho HorikoshiDivision of Infectious Diseases, Department of Pediatrics, Tokyo Metropolitan Children's Medical Center, Tokyo 183-8561, Japan.
Nobuaki InoueDepartment of Human Resources and Development, National Center for Global Health and Medicine, Tokyo 162-8655, Japan.
Tokyo Metropolitan Children's Medical Center · JPHirosaki University · JPNational Center for Global Health and Medicine · JP

Funding

Clinical Research Fund of the Tokyo Metropolitan Government 2014-2016
6 · The paper itself

Abstract

(1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational study using a prospective registry including febrile young infants (aged < 90 days) who visited a pediatric emergency department with a core body temperature of 38.0 °C or higher and 36.0 °C or lower. Univariate and logistic regression analyses were conducted to determine the predictor (s) of successful sepsis bundle completion. (3) Results: Of the 323 registered patients, 118 patients with suspected sepsis were analyzed, and 38 patients (32.2%) received a bundle-compliant treatment. Among potential variables, such as age, sex, and vital sign parameters, the logistic regression analysis showed that heart rate (odds ratio: OR 1.02; 95% confidence interval: 1.00-1.04) is a significant predictor of the completion of a 1-h sepsis bundle. (4) Conclusions: We found that tachycardia facilitated the sepsis recognition and promoted the successful completion of a 1-h sepsis bundle for young infants with suspected septic shock and a possible indicator for improving the quality of the team-based sepsis management.

Indexed as

1-h bundleinfantssepsistachycardia

Identifiers

PMID34827352
PMCPMC8615069
OpenAlexW3216134333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.