ArticleAntibiotics (Basel, Switzerland)2021
Is There a Difference in Clinical Features, Microbiological Epidemiology and Effective Empiric Antimicrobial Therapy Comparing Healthcare-Associated and Community-Acquired Vertebral Osteomyelitis?
Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Primary septic arthritis in the elderly - a forgotten killer? Five-year survival and risk factors in a retrospective cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Early and late mortality in vertebral osteomyelitis: who dies within the first year after diagnosis.Infection · 2025Article
- A fatal case of pyogenic spondylitis rapidly progressing to epidural abscess caused by a novel ST-type methicillin-susceptibleGHM open · 2025Article
- Survival and risk factor analysis in patients with septic arthritis: a retrospective study of 192 cases.BMC infectious diseases · 2025Article
- Development and validation of a prognostic nomogram model for severe osteomyelitis patients.Scientific reports · 2025Article
- Do not treat ghosts: anti-methicillin-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- [Antibiotics (Basel, Switzerland) · 2024Article
- Intradural Extramedullary Pyogenic Abscess: Incidence, Management, and Clinical Outcomes in 45 Patients With a Mean Follow Up of 2 Years.Global spine journal · 2024Article
- [Importance of local antibiotics in the prophylaxis and treatment of fracture-associated infections].Unfallchirurgie (Heidelberg, Germany) · 2024Review
- Anterior Column Reconstruction of Destructive Vertebral Osteomyelitis at the Thoracolumbar Spine with an Expandable Vertebral Body Replacement Implant: A Retrospective, Monocentric Radiological Cohort Analysis of 24 Cases.Journal of clinical medicine · 2024Article
- Midterm survival and risk factor analysis in patients with pyogenic vertebral osteomyelitis: a retrospective study of 155 cases.Frontiers in surgery · 2024Article
- In-Hospital Mortality from Spondylodiscitis: Insights from a Single-Center Retrospective Study.Journal of clinical medicine · 2023Article
- Risk Factors for the In-Hospital Mortality in Pyogenic Vertebral Osteomyelitis: A Cross-Sectional Study on 9753 Patients.Journal of clinical medicine · 2023Article
- Concentrations of Co-Administered Meropenem and Vancomycin in Spinal Tissues Relevant for the Treatment of Pyogenic Spondylodiscitis-An Experimental Microdialysis Study.Antibiotics (Basel, Switzerland) · 2023Article
- The Epidemiology of Spondylodiscitis in Germany: A Descriptive Report of Incidence Rates, Pathogens, In-Hospital Mortality, and Hospital Stays between 2010 and 2020.Journal of clinical medicine · 2023Article
- Long-term patient-related quality of life outcomes and ICD-10 symptom rating (ISR) of patients with pyogenic vertebral osteomyelitis: What is the psychological impact of this life-threatening disease?European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Mortality, complication risks, and clinical outcomes after surgical treatment of spinal epidural abscess: a comparative analysis of patients aged 18-64 years, 65-79 years, and ≥ 80 years, with a 3-year follow-up.Neurosurgical review · 2023Article
- Prevention of implant-associated spinal infections: the GAID-protocol.Frontiers in surgery · 2023Article
- Fracture-related infection.Nature reviews. Disease primers · 2022Review
- [Current practice of empiric antibiotic treatment for spondylodiscitis].Orthopadie (Heidelberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmpiric antibiotic therapy for suspected vertebral osteomyelitis (VO) should be initiated immediately in severely ill patients, and might be necessary for culture-negative VO. The current study aimed to identify differences between community-acquired (CA) and healthcare-associated (HA) VO in terms of clinical presentation, causative pathogens, and antibiotic susceptibility.
methodsCases of adult patients with VO treated at a German university orthopaedic trauma center between 2000 and 2020 were retrospectively reviewed. Patient history was used to distinguish between CA and HA VO. Susceptibility of antibiotic regimens was assessed based on antibiograms of the isolated pathogens.
resultsA total of 155 patients (with a male to female ratio of 1.3; and a mean age of 66.1 ± 12.4 years) with VO were identified. In 74 (47.7%) patients, infections were deemed healthcare-associated. The most frequently identified pathogens were
conclusionHealthcare association is common in VO. The susceptibility pattern of underlying pathogens differs from CAVO. When choosing an empiric antibiotic, combination therapy must be considered.
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