Evidence map›Paper›PMID 34827332›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Beneficial Effects of Anticoagulants on the Clinical Outcomes of COVID-19 Patients.

Zubia Jamil, Azmat Ali Khan, Samreen Khalid, Muhammad Asghar, Khalid Muhammad, Yasir Waheed

Open access · goldAbstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Efficacy and Safety of Direct Oral Anticoagulants Compared With Heparin for Preventing Thromboembolism in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Zubia JamilDepartment of Medicine, Foundation University Medical College, Foundation University Islamabad, Islamabad 44000, Pakistan.
Azmat Ali KhanPharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0001-5955-3783
Samreen KhalidDepartment of Medicine, Foundation University Medical College, Foundation University Islamabad, Islamabad 44000, Pakistan.
Muhammad AsgharDivision of Infectious Diseases, Department of Medicine Solna, Karolinska Institutet, 17177 Stockholm, Sweden.ORCID 0000-0002-9017-2206
Khalid MuhammadDepartment of Biology, College of Sciences, United Arab Emirates University, Al Ain 15551, United Arab Emirates.ORCID 0000-0001-6488-1722
Yasir WaheedMultidisciplinary Lab, Foundation University Medical College, Foundation University Islamabad, Islamabad 44000, Pakistan.ORCID 0000-0002-5789-4215
Foundation University Islamabad · PKKarolinska University Hospital · SEKing Saud University · SAUnited Arab Emirates University · AE

Funding

King Saud University RSP-2021/339
6 · The paper itself

Abstract

(1) Background: Severe coronavirus disease can be complicated by a hypercoagulable state in conjunction with sepsis, increasing the risk of venous thromboembolism. This study aimed to observe the effect of anticoagulants on 30-day high-dependency unit (HDU) outcomes of moderate to severe coronavirus disease 2019 (COVID-19) patients of a tertiary care hospital at Rawalpindi, Pakistan. (2) Methods: A retrospective propensity-based case-control study was carried out to examine COVID-19 patients admitted to the HDU. Patient groups who did and did not receive anticoagulants were labeled as "anticoagulant" and "non-anticoagulant", respectively. Case-control matching (1:1) was performed via propensity scores (calculated by a regression model). Kaplan-Meier and logrank analyses were used to study survival probability. Single predictors of outcomes were determined by Cox regression analysis. (3) Results: The anticoagulant group had elevated D-dimers, advanced age, more comorbidities and a higher frequency of severe disease compared to the non-anticoagulant group (

Indexed as

acute respiratory distress syndromeCOVID-19enoxaparinheparinpulmonary embolismSARS-CoV-2

Identifiers

PMID34827332
PMCPMC8615249
OpenAlexW3211492316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.