Evidence map›Paper›PMID 34827314›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Artificial Intelligence and Antibiotic Discovery.

Liliana David, Anca Monica Brata, Cristina Mogosan, Cristina Pop, Zoltan Czako, Lucian Muresan, Abdulrahman Ismaiel, Dinu Iuliu Dumitrascu, Daniel Corneliu Leucuta, Mihaela Fadygas Stanculete and 2 more

Abstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Bacteriocins fromFrontiers in microbiology · 2026
    Review
  6. Glycoconjugate Vaccines Against Nosocomial Klebsiella pneumoniae Infections.Advances in experimental medicine and biology · 2026
    Article
  7. CombattingAntibiotics (Basel, Switzerland) · 2025
    Review
  8. Review
  9. FDA-Approved Antibacterials and Echinocandins.Antibiotics (Basel, Switzerland) · 2025
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Antibacterial Activity of Nanostructured Zinc Oxide Tetrapods.International journal of molecular sciences · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liliana David2nd Medical Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.ORCID 0000-0001-5442-3138
Anca Monica BrataFaculty of Environmental Protection, University of Oradea, 410048 Oradea, Romania.ORCID 0000-0002-7665-3185
Cristina MogosanDepartment of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.ORCID 0000-0002-6854-2194
Cristina PopDepartment of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.ORCID 0000-0002-9088-8589
Zoltan CzakoDepartment of Computer Science, Technical University of Cluj-Napoca, 400027 Cluj-Napoca, Romania.ORCID 0000-0001-7497-0251
Lucian MuresanDepartment of Cardiology, "Emile Muller" Hospital, 68200 Mulhouse, France.ORCID 0000-0001-8314-4859
Abdulrahman Ismaiel2nd Medical Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.ORCID 0000-0001-7435-271X
Dinu Iuliu DumitrascuDepartment of Anatomy, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
Daniel Corneliu LeucutaDepartment of Medical Informatics and Biostatistics, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0003-4218-8622
Mihaela Fadygas StanculeteDepartment of Neurosciences, Discipline of Psychiatry and Pediatric Psychiatry, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
Irina IaruDepartment of Pharmacology, Physiology and Pathophysiology, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.
Stefan Lucian Popa2nd Medical Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania.ORCID 0000-0002-5508-2598

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over recent decades, a new antibiotic crisis has been unfolding due to a decreased research in this domain, a low return of investment for the companies that developed the drug, a lengthy and difficult research process, a low success rate for candidate molecules, an increased use of antibiotics in farms and an overall inappropriate use of antibiotics. This has led to a series of pathogens developing antibiotic resistance, which poses severe threats to public health systems while also driving up the costs of hospitalization and treatment. Moreover, without proper action and collaboration between academic and health institutions, a catastrophic trend might develop, with the possibility of returning to a pre-antibiotic era. Nevertheless, new emerging AI-based technologies have started to enter the field of antibiotic and drug development, offering a new perspective to an ever-growing problem. Cheaper and faster research can be achieved through algorithms that identify hit compounds, thereby further accelerating the development of new antibiotics, which represents a vital step in solving the current antibiotic crisis. The aim of this review is to provide an extended overview of the current artificial intelligence-based technologies that are used for antibiotic discovery, together with their technological and economic impact on the industrial sector.

Indexed as

antibiotic developmentantibiotic discoveryantibiotic resistanceartificial intelligenceautomated antibiotic discoverycomputer-aided drug designdeep learningfuture of medicinemachine learning

Identifiers

PMID34827314
PMCPMC8614913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.