Evidence map›Paper›PMID 34827300›Full record

ArticleAntibiotics (Basel, Switzerland)2021

Wastewater-Based Surveillance of Antibiotic Resistance Genes Associated with Tuberculosis Treatment Regimen in KwaZulu Natal, South Africa.

Hlengiwe N Mtetwa, Isaac D Amoah, Sheena Kumari, Faizal Bux, Poovendhree Reddy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Environmental surveillance of pathogens in Africa.Applied and environmental microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hlengiwe N MtetwaDepartment of Community Health Studies, Faculty of Health Sciences, Durban University of Technology, P.O. Box 1334, Durban 4000, South Africa.
Isaac D AmoahInstitute for Water and Wastewater Technology (IWWT), Durban University of Technology, P.O. Box 1334, Durban 4000, South Africa.
Sheena KumariInstitute for Water and Wastewater Technology (IWWT), Durban University of Technology, P.O. Box 1334, Durban 4000, South Africa.
Faizal BuxInstitute for Water and Wastewater Technology (IWWT), Durban University of Technology, P.O. Box 1334, Durban 4000, South Africa.ORCID 0000-0002-8108-0238
Poovendhree ReddyDepartment of Community Health Studies, Faculty of Health Sciences, Durban University of Technology, P.O. Box 1334, Durban 4000, South Africa.ORCID 0000-0003-0197-8951
Durban University of Technology · ZA

Funding

South African Medical Research Council (SAMRC) as a sub-grant received from the Bill and Melinda Gates Foundation 96086
6 · The paper itself

Abstract

Essential components of public health include strengthening the surveillance of infectious diseases and developing early detection and prevention policies. This is particularly important for drug-resistant tuberculosis (DR-TB), which can be explored by using wastewater-based surveillance. This study aimed to use molecular techniques to determine the occurrence and concentration of antibiotic-resistance genes (ARGs) associated with tuberculosis (TB) resistance in untreated and treated wastewater. Raw/untreated and treated (post-chlorination) wastewater samples were taken from three wastewater treatment plants (WWTPs) in South Africa. The ARGs were selected to target drugs used for first- and second-line TB treatment. Both conventional polymerase chain reaction (PCR) and the more advanced droplet digital PCR (ddPCR) were evaluated as surveillance strategies to determine the distribution and concentration of the selected ARGs. The most abundant ARG in the untreated wastewater was the

Indexed as

antibiotic resistant genesdroplet digital PCRmultidrug-resistant tuberculosiswastewaterwastewater-based epidemiology

Identifiers

PMID34827300
PMCPMC8614817
OpenAlexW3214716678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.