Evidence map›Paper›PMID 34827236›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Local/Topical Antibiotics for Peri-Implantitis Treatment: A Systematic Review.

Pier Carmine Passarelli, Andrea Netti, Michele Antonio Lopez, Eleonora Favetti Giaquinto, Giuseppe De Rosa, Gianmarco Aureli, Alina Bodnarenko, Piero Papi, Anna Starzyńska, Giorgio Pompa and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  11. Local Oxygen-Based Therapy (blueMedicina (Kaunas, Lithuania) · 2024
    Review
  12. Article
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  14. Article
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  17. Metabolic Conditions and Peri-Implantitis.Antibiotics (Basel, Switzerland) · 2022
    Review
  18. Managing Oral Health in the Context of Antimicrobial Resistance.International journal of environmental research and public health · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Pier Carmine PassarelliDepartment of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the "Sacred Heart", 00168 Rome, Italy.
Andrea NettiDepartment of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the "Sacred Heart", 00168 Rome, Italy.
Michele Antonio LopezUnit of Otolaryngology, University Campus Bio-Medico, 00128 Rome, Italy.
Eleonora Favetti GiaquintoDepartment of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the "Sacred Heart", 00168 Rome, Italy.
Giuseppe De RosaDepartment of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the "Sacred Heart", 00168 Rome, Italy.
Gianmarco AureliDepartment of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the "Sacred Heart", 00168 Rome, Italy.
Alina BodnarenkoDepartment of Oral Surgery, Medical University of Gdańsk, 7 Dębinki Street, 80-211 Gdańsk, Poland.
Piero PapiDepartment of Oral and Maxillofacial Sciences, Policlinico Umberto I, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0003-2564-530X
Anna StarzyńskaDepartment of Oral Surgery, Medical University of Gdańsk, 7 Dębinki Street, 80-211 Gdańsk, Poland.ORCID 0000-0001-6900-0429
Giorgio PompaDepartment of Oral and Maxillofacial Sciences, Policlinico Umberto I, "Sapienza" University of Rome, 00161 Rome, Italy.
Antonio D'AddonaDepartment of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the "Sacred Heart", 00168 Rome, Italy.
Università Cattolica del Sacro Cuore · ITGdańsk Medical University · PLPoliclinico Umberto I · ITUniversità Campus Bio-Medico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most studies indicate that the mechanical removal of the bacterial biofilm from the implant surface is the central goal of peri-implantitis therapy. However, controversial results in the treatment of peri-implantitis have led to the consideration of additional strategies that include surgical approaches and chemical adjuvants. Local/topical antibiotics, such as minocycline, azithromycin, tetracycline, amoxicillin, doxycycline, and metronidazole, may improve the efficacy of the definitive treatment of the disease, but the lack of conclusive findings prevents their use in clinical practice. This systematic review aimed to evaluate the effect of local/topical antibiotics for peri-implantitis treatment. Randomised controlled studies (RCT) on patients with peri-implantitis and comparing the efficacy of local/topical antibiotics vs. placebo or mechanical debridement were included. A systematic search strategy was carried out using three registered databases (PubMed, Web of Science, and Scopus). RoB2 was used to assess risk of bias. Five RCTs were identified (

Indexed as

chemical adjuvantsclinical practice guidelineslocal antibioticsminocyclineperi-implantitisperi-implant mucositis

Identifiers

PMID34827236
PMCPMC8615130
OpenAlexW3210043750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.