Evidence map›Paper›PMID 34827219›Full record

ReviewAntibiotics (Basel, Switzerland)2021

Lipid Transfer Proteins (LTPs)-Structure, Diversity and Roles beyond Antimicrobial Activity.

Vinícius Costa Amador, Carlos André Dos Santos-Silva, Lívia Maria Batista Vilela, Marx Oliveira-Lima, Mireli de Santana Rêgo, Ricardo Salas Roldan-Filho, Roberta Lane de Oliveira-Silva, Ayug Bezerra Lemos, Wilson Dias de Oliveira, José Ribamar Costa Ferreira-Neto and 2 more

Abstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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  15. Production of Plant Proteins and Peptides with Pharmacological Potential.Advances in biochemical engineering/biotechnology · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Effects of aMembranes · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Vinícius Costa AmadorBioscience Centre, Genetics Department, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.ORCID 0000-0002-7946-5665
Carlos André Dos Santos-SilvaDepartment of Advanced Diagnostics, Institute for Maternal and Child Health-IRCCS, Burlo Garofolo, 34100 Trieste, Italy.ORCID 0000-0003-0020-9763
Lívia Maria Batista VilelaBioscience Centre, Genetics Department, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.
Marx Oliveira-LimaBioscience Centre, Genetics Department, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.ORCID 0000-0003-2021-6805
Mireli de Santana RêgoBioscience Centre, Genetics Department, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.
Ricardo Salas Roldan-FilhoBioscience Centre, Genetics Department, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.ORCID 0000-0002-0833-8052
Roberta Lane de Oliveira-SilvaGeneral Microbiology Laboratory, Agricultural Science Campus, Universidade Federal do Vale do São Francisco, Petrolina 56300-990, Brazil.ORCID 0000-0003-1876-0094
Ayug Bezerra LemosBioscience Centre, Genetics Department, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.
Wilson Dias de OliveiraBioscience Centre, Genetics Department, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.
José Ribamar Costa Ferreira-NetoBioscience Centre, Genetics Department, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.ORCID 0000-0003-0935-203X
Sérgio CrovellaDepartment of Biological and Environmental Sciences, College of Arts and Science, Qatar University, Doha 1883, Qatar.
Ana Maria Benko-IsepponBioscience Centre, Genetics Department, Universidade Federal de Pernambuco, Recife 50670-420, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid transfer proteins (LTPs) are among the most promising plant-exclusive antimicrobial peptides (AMPs). They figure among the most challenging AMPs from the point of view of their structural diversity, functions and biotechnological applications. This review presents a current picture of the LTP research, addressing not only their structural, evolutionary and further predicted functional aspects. Traditionally, LTPs have been identified by their direct isolation by biochemical techniques, whereas omics data and bioinformatics deserve special attention for their potential to bring new insights. In this context, new possible functions have been identified revealing that LTPs are actually multipurpose, with many additional predicted roles. Despite some challenges due to the toxicity and allergenicity of LTPs, a systematic review and search in patent databases, indicate promising perspectives for the biotechnological use of LTPs in human health and also plant defense.

Indexed as

bioinformaticscationic peptidesomics databasesprediction directed analysis

Identifiers

PMID34827219
PMCPMC8615156

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.