Evidence map›Paper›PMID 34827195›Full record

ReviewBiology2021

Shifting Perspectives of Translational Research in Bio-Bactericides: Reviewing the

Anastasia Dimopoulou, Ioannis Theologidis, Adamantia Varympopi, Dimitris Papafotis, Glykeria Mermigka, Aliki Tzima, Nick J Panopoulos, Nicholas Skandalis

Open access · goldAbstract readReview
In one paragraph

Review in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2026
    Review
  2. Article
  3. Review
  4. Comparative Study ofBiology · 2024
    Article
  5. Lipopeptides from Bacillus: unveiling biotechnological prospects-sources, properties, and diverse applications.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Antibacterial Activity of Copper Nanoparticles againstInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Anastasia DimopoulouInstitute of Molecular Biology and Biotechnology, FORTH, 70013 Heraklion, Greece.
Ioannis TheologidisLaboratory of Pesticides' Toxicology, Benaki Phytopathological Institute, 14561 Athens, Greece.ORCID 0000-0002-6658-4980
Adamantia VarympopiEnzyme and Microbial Biotechnology Unit, Department of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Dimitris PapafotisEnzyme and Microbial Biotechnology Unit, Department of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece.
Glykeria MermigkaInstitute of Molecular Biology and Biotechnology, FORTH, 70013 Heraklion, Greece.
Aliki TzimaLaboratory of Plant Pathology, Department of Crop Production, School of Agricultural Production Infrastructure and Environment, Faculty of Crop Science, Agricultural University of Athens, 11855 Athens, Greece.
Nick J PanopoulosDepartment of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720, USA.
Nicholas SkandalisHealth Sciences Campus, Keck School of Medicine, University of Southern California, 1441 Eastlake Ave, Los Angeles, CA 90033, USA.ORCID 0000-0002-4236-8909
FORTH Institute of Molecular Biology and Biotechnology · GRNational and Kapodistrian University of Athens · GRAgricultural University of Athens · GRBenaki Phytopathological Institute · GRUniversity of California, Berkeley · USUniversity of Southern California · US

Funding

BASF SE PAR00415-1
6 · The paper itself

Abstract

Bacterial biological control agents (BCAs) have been increasingly used against plant diseases. The traditional approach to manufacturing such commercial products was based on the selection of bacterial species able to produce secondary metabolites that inhibit mainly fungal growth in optimal media. Such species are required to be massively produced and sustain long-term self-storage. The endpoint of this pipeline is large-scale field tests in which BCAs are handled as any other pesticide. Despite recent knowledge of the importance of BCA-host-microbiome interactions to trigger plant defenses and allow colonization, holistic approaches to maximize their potential are still in their infancy. There is a gap in scientific knowledge between experiments in controlled conditions for optimal BCA and pathogen growth and the nutrient-limited field conditions in which they face niche microbiota competition. Moreover, BCAs are considered to be safe by competent authorities and the public, with no side effects to the environment; the OneHealth impact of their application is understudied. This review summarizes the state of the art in BCA research and how current knowledge and new biotechnological tools have impacted BCA development and application. Future challenges, such as their combinational use and ability to ameliorate plant stress are also discussed. Addressing such challenges would establish their long-term use as centerfold agricultural pesticides and plant growth promoters.

Indexed as

bacterial biological controlBCAsbiological control agentsenvironmental impact

Identifiers

PMID34827195
PMCPMC8614995
OpenAlexW3211372937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.