ArticleBiology2021
Bovine Follicular Fluid Derived Extracellular Vesicles Modulate the Viability, Capacitation and Acrosome Reaction of Bull Spermatozoa.
Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Sex differences in urinary extracellular vesicles originating from the genitourinary system in health and disease.American journal of physiology. Renal physiology · 2026Review
- Cryoprotective effects of cholesterol-loaded cyclodextrin and iodixanol on ram sperm: assessment of post-thaw quality and in vitro fertilization outcomes.BMC veterinary research · 2026Article
- Detection of Organelle-Specific Dyes Labeled Extracellular Vesicles with Colocalization-Fluorescence Nanoparticle Tracking Analysis.ACS omega · 2026Article
- Does extracellular vesicle specificity truly exist?Cell communication and signaling : CCS · 2026Review
- [The role of extracellular vesicles in early embryo development and their application in assisted reproductive technologies].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Review
- Extracellular Vesicles in Reproduction: Biology, Production, and Potential Applications in Livestock Breeding.Reproduction in domestic animals = Zuchthygiene · 2025Review
- Extracellular vesicles in dairy cattle: research progress and prospects for practical applications.Journal of animal science and biotechnology · 2025Review
- Extracellular vesicles from different regions of the female reproductive tract promote spermatozoa motility and support capacitation.Scientific reports · 2025Article
- Follicular-fluid extracellular vesicles support energy metabolism of bovine oocytes, improving blastocyst development and quality†.Biology of reproduction · 2025Article
- Engineered extracellular vesicles: a breakthrough approach to overcoming sperm cryopreservation challenges.Reproductive biology and endocrinology : RB&E · 2025Review
- Incubation of semen with human follicular fluid improves the antioxidant status and quality of spermatozoa after freezing-thawing.Reproduction & fertility · 2025Article
- Redox profiling of preovulatory follicular fluid in the donkey is species-specific, and contributes to modulate sperm function.Scientific reports · 2025Article
- Proteomic and functional analysis of alpaca (Frontiers in veterinary science · 2025Article
- The evolving roles of extracellular vesicles in embryo-maternal communication.Communications biology · 2024Review
- Systematic characterization of extracellular vesicles from potato (Frontiers in plant science · 2024Article
- Do extracellular vesicles have specific target cells?; Extracellular vesicle mediated embryo maternal communication.Frontiers in molecular biosciences · 2024Article
- Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro.Journal of cell communication and signaling · 2023Article
- Characterization of bovine uterine fluid extracellular vesicles proteomic profiles at follicular and luteal phases of the oestrous cycle.Veterinary research communications · 2023Article
- Female reproductive fluids 'rescue' sperm from phenotypic ageing in an external fertilizer.Proceedings. Biological sciences · 2023Article
- Rhythm of the First Language: Dynamics of Extracellular Vesicle-Based Embryo-Maternal Communication in the Pre-Implantation Microenvironment.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
While follicular fluid (FF) is known to enhance the functional properties of spermatozoa, the role of FF-derived extracellular vesicles (EVs) in this respect is unknown. We hypothesized that bovine FF EVs convey signals to spermatozoa supporting sperm viability, inducing sperm capacitation and acrosome reaction. In this study, the effects of bovine FF EVs on sperm functions are evaluated. Irrespective of the size of the follicles which FF EVs had originated from, they were capable of supporting sperm viability, inducing capacitation and acrosome reaction. These effects were specific to the source of bovine FF EVs, as human-cell-line-derived or porcine FF EVs did not affect spermatozoa viability or induced capacitation and acrosome reaction. A minimum of 5 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.