Evidence map›Paper›PMID 34827117›Full record

ArticleBiology2021

Dose-Dependent Suppression of Human Glioblastoma Xenograft Growth by Accelerator-Based Boron Neutron Capture Therapy with Simultaneous Use of Two Boron-Containing Compounds.

Vladimir Kanygin, Ivan Razumov, Alexander Zaboronok, Evgenii Zavjalov, Aleksandr Kichigin, Olga Solovieva, Alphiya Tsygankova, Tatiana Guselnikova, Dmitrii Kasatov, Tatiana Sycheva and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Vladimir KanyginLaboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia.
Ivan RazumovLaboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia.ORCID 0000-0002-6756-1457
Alexander ZaboronokLaboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia.ORCID 0000-0002-6833-9866
Evgenii ZavjalovLaboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia.ORCID 0000-0002-9412-3874
Aleksandr KichiginLaboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia.
Olga SolovievaLaboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia.
Alphiya TsygankovaLaboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia.ORCID 0000-0001-7126-276X
Tatiana GuselnikovaLaboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia.
Dmitrii KasatovLaboratory of Medical and Biological Problems of BNCT, Novosibirsk State University, 1 Pirogov Str., 630090 Novosibirsk, Russia.
Tatiana SychevaBudker Institute of Nuclear Physics, Siberian Branch of Russian Academy of Sciences, 11, Acad. Lavrentieva Ave., 630090 Novosibirsk, Russia.
Bryan J MathisInternational Medical Center, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba 305-8576, Ibaraki, Japan.ORCID 0000-0002-9879-8289
Sergey TaskaevBudker Institute of Nuclear Physics, Siberian Branch of Russian Academy of Sciences, 11, Acad. Lavrentieva Ave., 630090 Novosibirsk, Russia.ORCID 0000-0002-5313-2563
Novosibirsk State University · RUBudker Institute of Nuclear Physics · RUUniversity of Tsukuba · JPUniversity of Tsukuba Hospital · JP

Funding

MINISTRY OF SCIENCE AND HIGHER EDUCATION OF THE RUSSIAN FEDERATION 121031700315-2Russian Foundation for Basic Research 18-29-01007Russian Science Foundation 19-72-30005
6 · The paper itself

Abstract

(1) Background: Developments in accelerator-based neutron sources moved boron neutron capture therapy (BNCT) to the next phase, where new neutron radiation parameters had to be studied for the treatment of cancers, including brain tumors. We aimed to further improve accelerator-BNCT efficacy by optimizing dosimetry control, beam parameters, and combinations of boronophenylalanine (BPA) and sodium borocaptate (BSH) administration in U87MG xenograft-bearing immunodeficient mice with two different tumor locations. (2) Methods: The study included two sets of experiments. In Experiment #1, BPA only and single or double irradiation in higher doses were used, while, in Experiment #2, BPA and BSH combinations and single or double irradiation with dosage adjustment were analyzed. Mice without treatment or irradiation after BPA or BPA+BSH injection were used as controls. (3) Results: Irradiation parameter adjustment and BPA and BSH combination led to 80-83% tumor-growth inhibition index scores, irradiation:BNCT ratios of 1:2, and increases in animal life expectancy from 9 to 107 days. (4) Conclusions: Adjustments in dosimetry control, calculation of irradiation doses, and combined use of two

Indexed as

accelerator-based neutron sourceanimal tumor modelboron compoundsboron neutron capture therapyboronophenylalanineglioblastomasodium borocaptate

Identifiers

PMID34827117
PMCPMC8615214
OpenAlexW3208252743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.