Evidence map›Paper›PMID 34827089›Full record

ArticleBiology2021

PPARα, δ and FOXO1 Gene Silencing Overturns Palmitate-Induced Inhibition of Pyruvate Oxidation Differentially in C2C12 Myotubes.

Hung-Che Chien, Despina Constantin, Paul L Greenhaff, Dumitru Constantin-Teodosiu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Hung-Che ChienQueen's Medical Centre, Division of Physiolgy, Pharmacology and Neuroscince, School of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK.ORCID 0000-0002-2500-0299
Despina ConstantinQueen's Medical Centre, Division of Physiolgy, Pharmacology and Neuroscince, School of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK.
Paul L GreenhaffQueen's Medical Centre, Division of Physiolgy, Pharmacology and Neuroscince, School of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK.ORCID 0000-0003-4403-0490
Dumitru Constantin-TeodosiuQueen's Medical Centre, Division of Physiolgy, Pharmacology and Neuroscince, School of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK.
University of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanisms by which free fatty acids (FFA) inhibit muscle glucose oxidation is still elusive. We recently showed that C2C12 myotubes treated with palmitate (PAL) presented with greater protein expression levels of PDK4 and transcription factors

Indexed as

free fatty acidsfuel selectionmetabolic inflexibilitymuscle cell

Identifiers

PMID34827089
PMCPMC8614693
OpenAlexW3211234032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.