Evidence map›Paper›PMID 34826638›Full record

ArticlePhotodiagnosis and photodynamic therapy2022

A Brazilian multicenter pilot case series on the efficacy of photobiomodulation therapy for COVID-19-related taste dysfunction.

Luana Campos, Luís Eduardo Silva Soares, Giuseppina Berlingieri, Marcia Christina Camargo Hernandes Ramires, Milena Miranda Goulart Guirado, Luciana Aparecida de Oliveira P Lyra, Inessa Solek Teixeira, Patrícia Costa Oliveira, Cristina Maria Arvate Alvares, Luiz Felipe Palma

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Photodiagnosis and photodynamic therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Luana CamposGraduate Program in Implantology, University of Santo Amaro, School of Dentistry. São Paulo, SP, Brazil; Study Group of Laser and Health Institute. São Paulo, SP, Brazil.
Luís Eduardo Silva SoaresStudy Group of Laser and Health Institute. São Paulo, SP, Brazil; Graduate Program in Biomedical Engineering, University of Vale do Paraíba, Research and Development Institute. São José dos Campos, SP, Brazil.
Giuseppina BerlingieriStudy Group of Laser and Health Institute. São Paulo, SP, Brazil.
Marcia Christina Camargo Hernandes RamiresStudy Group of Laser and Health Institute. São Paulo, SP, Brazil; Doutor José de Carvalho Florence Hospital. São José dos Campos, SP, Brazil.
Milena Miranda Goulart GuiradoStudy Group of Laser and Health Institute. São Paulo, SP, Brazil; Doutor José de Carvalho Florence Hospital. São José dos Campos, SP, Brazil.
Luciana Aparecida de Oliveira P LyraStudy Group of Laser and Health Institute. São Paulo, SP, Brazil; Scholl of Health Science, Universidade Positivo. Curitiba, PR, Brazil.
Inessa Solek TeixeiraStudy Group of Laser and Health Institute. São Paulo, SP, Brazil; Imperial Charity Hospital. Florianópolis, SC, Brazil.
Patrícia Costa OliveiraStudy Group of Laser and Health Institute. São Paulo, SP, Brazil; Instituto Federal do Paraná, Campus Londrina. Londrina, PR, Brazil.
Cristina Maria Arvate AlvaresGraduate Program in Implantology, University of Santo Amaro, School of Dentistry. São Paulo, SP, Brazil.
Luiz Felipe PalmaGraduate Dentistry Program, Ibirapuera University. São Paulo, SP, Brazil. Electronic address: luizfelipep@hotmail.com.
Universidade de Santo Amaro · BRInstituto Federal de Educação Ciência e Tecnologia do Paraná · BRUniversidade do Vale do Paraíba · BRUniversidade Ibirapuera · BRUniversidade Positivo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimAmong the most common symptoms of COVID-19 is taste dysfunction, which has a ranging clinical presentation. As well as its pathophysiology remains to be unclear, there is not enough information about the efficacy and safety of the available treatments. This study aims to report a series of cases using PBMT for the management of COVID-19-related taste impairment. CASE SERIES: 8 female and 2 male patients sought medical help for taste impairment (either partially or completely) after COVID-19 infection. Photobiomodulation therapy (PBMT) on the tongue mucosa was then proposed but with 3 different protocols. Taste perception at baseline and before every laser session was evaluated using a visual analog scale. Irrespective of the PBMT protocol, taste recovery was noted in all cases but with varying degrees of improvement.

conclusiongiven the high prevalence rates of taste dysfunction in COVID-19 patients and the lack of information about the available treatments, PBMT seems to be a promising therapeutic modality but not dependent on the total number of laser sessions and the interval between them. The choice of the most suitable laser protocol as well as the knowledge of the exact photonic mechanisms, however, need to be better studied.

Indexed as

COVID-19Low-Level Light TherapyPhotochemotherapyFemaleHumansMaleSARS-CoV-2Taste DisordersCOVID-19laserslow-level light therapySARS-CoV-2taste perception

Identifiers

PMID34826638
PMCPMC8610561
OpenAlexW3216447094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.