ArticleThe Journal of molecular diagnostics : JMD2022
SARS-CoV-2 RT-qPCR Test Detection Rates Are Associated with Patient Age, Sex, and Time since Diagnosis.
Article in The Journal of molecular diagnostics : JMD, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Cycle Threshold (Ct) Value Trends in COVID-19: Analyzing Gender, Age, and Severity Factors Across Major Waves in India.Immunity, inflammation and disease · 2026Article
- Quantitatively assessing early detection strategies for mitigating COVID-19 and future pandemics.Nature communications · 2023Article
- Quantitatively assessing early detection strategies for mitigating COVID-19 and future pandemics.medRxiv : the preprint server for health sciences · 2023Article
- Article
- Long COVID: major findings, mechanisms and recommendations.Nature reviews. Microbiology · 2023Review
- Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device.Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Insights from a workplace SARS-CoV-2 specimen collection program, with genomes placed into global sequence phylogeny.PloS one · 2023Article
- Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID.EBioMedicine · 2022Article
- Waning of SARS-CoV-2 booster viral-load reduction effectiveness.Nature communications · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantifying the detection rate of the widely used quantitative RT-PCR (RT-qPCR) test for severe acute respiratory syndrome coronavirus 2 and its dependence on patient demographic characteristics and disease progression is key in designing epidemiologic strategies. Analyzing 843,917 test results of 521,696 patients, a "positive period" was defined for each patient between diagnosis of coronavirus disease 2019 and the last positive test result. The fraction of positive test results within this period was then used to estimate detection rate. Regression analyses were used to determine associations of detection with time of sampling after diagnosis, patient demographic characteristics, and viral RNA copy number based on RT-qPCR cycle threshold values of the next positive test result. The overall detection rate in tests performed within 14 days after diagnosis was 83.1%. This rate was higher at days 0 to 5 after diagnosis (89.3%). Furthermore, detection rate was strongly associated with age and sex. Finally, the detection rate with the Allplex 2019-nCoV RT-qPCR kit was associated, at the single-patient level, with viral RNA copy number (P < 10
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