ReviewExperimental gerontology2022
Acute catabolic bone metabolism response to exercise in young and older adults: A narrative review.
Review in Experimental gerontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Influence of Nutrition Intervention on the P1NP and CTX-1 Response to an Acute Exercise Bout: A Systematic Review with Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- P1NP and β-CTX-1 Responses to a Prolonged, Continuous Running Bout in Young Healthy Adult Males: A Systematic Review with Individual Participant Data Meta-analysis.Sports medicine - open · 2023Pooled it
- The Bone Biomarker Response to an Acute Bout of Exercise: A Systematic Review with Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Weighted Vest Use or Resistance Exercise to Offset Weight Loss-Associated Bone Loss in Older Adults: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Load carriage aerobic exercise stimulates a transient rise in biochemical markers of bone formation and resorption.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Exercise-Induced Coronary Remodeling and the Atherosclerotic Paradox in Endurance Athletes: Toward a Unified Mechanobiological Framework.Journal of functional morphology and kinesiology · 2026Review
- Effects of Single, Maximal Intensity Exercise Unit on Selected Markers of Bone and Connective Tissue Turnover in Young Men.Journal of clinical medicine · 2026Article
- The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act.Obesity (Silver Spring, Md.) · 2025Review
- Physical activity and exercise within the context of obesity treatment: Enhancing health beyond weight loss.Journal of sport and health science · 2025Review
- Association of cardiorespiratory fitness with HR-pQCT bone parameters in older adults: the Study of Muscle, Mobility and Aging (SOMMA).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Coronary atherosclerosis in athletes: emerging concepts and preventive strategies.European heart journal · 2025Review
- Perspective: Promoting Healthy Aging through Nutrition: A Research Centers Collaborative Network Workshop Report.Advances in nutrition (Bethesda, Md.) · 2024Article
- Effect of acute resistance exercise on bone turnover in young adults before and after concurrent resistance and interval training.Physiological reports · 2024Article
- The effect of calcium supplementation on calcium and bone metabolism during load carriage in women: protocol for a randomised controlled crossover trial.BMC musculoskeletal disorders · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Exercise is recommended for cardiometabolic benefits and to preserve or improve bone health, especially for older adults at increased risk of fracture. However, exercise interventions have modest benefits on areal bone mineral density (aBMD), and exercise can lead to bone loss in young athletes under certain conditions. In this narrative review, we discuss evidence for a disruption in calcium homeostasis during exercise that may diminish the skeletal benefits of exercise. Topics include 1) a general overview of the effects of exercise on aBMD; 2) discussion of the exercise-induced disruption in calcium homeostasis; 3) factors that influence the magnitude of the exercise-induced disruption in calcium homeostasis, including age, sex, and exercise mode, intensity, and duration; 4) oral calcium supplementation to minimize the exercise-induced disruption in calcium homeostasis; and 5) potential for exercise-induced increase in parathyroid hormone to be both catabolic and anabolic to bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.