Evidence map›Paper›PMID 34826125›Full record

Trial reportDrugs in R&D2022

Coenzyme Q10 in the Treatment of Heart Failure with Preserved Ejection Fraction: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial.

Tal Y Samuel, Tal Hasin, Israel Gotsman, Tanya Weitzman, Fanny Ben Ivgi, Ziv Dadon, Elad Asher, Offer Amir, Michael Glikson, Ronny Alcalai and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drugs in R&D, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02779634 (The Effect of Ubiquinol Treatment on Cardiac Function in Patients With Heart Failure With Preserved Ejection Fraction), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02779634 phase2unknown statusnot on this map

The Effect of Ubiquinol Treatment on Cardiac Function in Patients With Heart Failure With Preserved Ejection Fraction

TypeinterventionalSponsorHadassah Medical OrganizationRan2016 to 2018Enrolled60ConditionsHeart FailureArmsubiquinol, Placebo
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Advances in Metabolic Remodeling and Intervention Strategies in Heart Failure.Journal of cardiovascular translational research · 2024
    Review
  15. Review
  16. Review
  17. Coenzyme Q10 Metabolism: A Review of Unresolved Issues.International journal of molecular sciences · 2023
    Review
  18. Review
  19. Heart Failure-Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10.Journal of cardiovascular development and disease · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Tal Y SamuelJesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Tal HasinJesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Israel GotsmanDepartment of Cardiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Tanya WeitzmanJesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Fanny Ben IvgiDepartment of Cardiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Ziv DadonJesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Elad AsherJesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Offer AmirDepartment of Cardiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Michael GliksonJesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel.
Ronny AlcalaiDepartment of Cardiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
David LeibowitzDepartment of Cardiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. oleibo@hadassah.org.il.
Shaare Zedek Medical Center · ILHadassah Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeart failure with preserved ejection fraction (HFpEF) is common in elderly people and is increasing in prevalence. No specific treatment for this condition exists. Coenzyme Q10 (CoQ10) is an essential cofactor for energy production, with reduced levels being noted in HF. Previous studies have suggested a possible role for CoQ10 in the treatment of HF. This study examined the effect of CoQ10 supplementation on diastolic function in HFpEF patients.

methodsWe conducted a prospective, randomized, double-blind, placebo-controlled trial including patients aged > 55 years presenting with New York Heart Association class II-IV heart failure symptoms and left ventricular ejection fraction > 50%, with impaired diastolic function. Echocardiography and levels of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) were performed at baseline and following 4 months of CoQ10 or placebo supplementation.

resultsA total of 39 patients were enrolled-19 in the CoQ10 group and 20 in the placebo group. Baseline clinical characteristics were similar between groups, while compliance was high and also similar between the CoQ10 and placebo groups. There was no significant effect of treatment on indices of diastolic function (difference in the lateral E/e' ratio: -0.86 ± 6.57 in the CoQ10 group, +0.18 ± 3.76 in the placebo group; p = 0.561) or on serum NT-proBNP levels (- 72 pg/mL vs. - 42 pg/mL; p = 0.195).

conclusionsIn this pilot trial in elderly patients with HFpEF, treatment with CoQ10 did not significantly affect echocardiographic indices of diastolic function and serum NT-proBNP levels.

trial registrationThis trial was registered in the US National Institutes of Health Clinical Trials Registry (ClinicalTrials.gov identifier: NCT02779634).

Indexed as

Heart Failure, DiastolicAgedDouble-Blind MethodHumansMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsProspective StudiesStroke VolumeUbiquinoneVentricular Function, Leftcoenzyme Q10Natriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Ubiquinone

Identifiers

PMID34826125
PMCPMC8885873
OpenAlexW3217505491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.