ArticleJournal of microbiology (Seoul, Korea)2022
Direct current exerts electricidal and bioelectric effects on Porphyromonas gingivalis biofilms partially via promoting oxidative stress and antibiotic transport.
Article in Journal of microbiology (Seoul, Korea), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 15 citations in OpenAlex.
- Smart biomaterials in restorative dentistry: Recent advances and future perspectives.Materials today. Bio · 2025Review
- Antibacterial Effect of Combined Electrolytic and Chemical Decontamination Methods on Dental Implant Surfaces: In Vitro Study.Clinical oral implants research · 2025Article
- Bioelectricity harvesting from microorganism: review of recent advancements in utilizing the bioelectric properties of fungi for powering small-scale robotic systems.Frontiers in fungal biology · 2025Review
- Antifungal Activity, Synergism with Fluconazole or Amphotericin B and Potential Mechanism of Direct Current againstAntibiotics (Basel, Switzerland) · 2024Article
- Bioelectric device for effective biofilm inflammation management of dental implants.Scientific reports · 2023Article
- Smart dental materials for antimicrobial applications.Bioactive materials · 2023Article
- A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections.Advanced materials (Deerfield Beach, Fla.) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Low electric current can inhibit certain microbial biofilms and enhance the efficacy of antimicrobials against them. This study investigated the electricidal and bioelectric effects of direct current (DC) against Porphyromonas gingivalis biofilms as well as the underlying mechanisms. Here, we firstly showed that DC significantly suppressed biofilm formation of P. gingivalis in time- and intensity-dependent manners, and markedly inhibited preformed P. gingivalis biofilms. Moreover, DC enhanced the killing efficacy of metronidazole (MTZ) and amoxicillin with clavulanate potassium (AMC) against the biofilms. Notably, DC-treated biofilms displayed upregulated intracellular ROS and expression of ROS related genes (sod, feoB, and oxyR) as well as porin gene. Interestingly, DC-induced killing of biofilms was partially reversed by ROS scavenger N-dimethylthiourea (DMTU), and the synergistic effect of DC with MTZ/AMC was weakened by small interfering RNA of porin gene (si-Porin). In conclusion, DC can exert electricidal and bioelectric effects against P. gingivalis biofilms partially via promotion of oxidative stress and antibiotic transport, which offers a promising approach for effective management of periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.