ArticleNeurotoxicity research2022
Hesperidin Preserves Cognitive Functions and Hippocampus Histological Architecture in Albino Wistar Rats Subjected to Stress Through Enhancement of Brain-Derived Neurotrophic Factor.
Article in Neurotoxicity research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Hesperidin mitigates cognitive and anxiety-like deficits by enhancing hippocampal antioxidant defenses, reducing neuroinflammation, and preventing neuronal apoptosis in a third-trimester-equivalent rat model of developmental ethanol neurotoxicity.IBRO neuroscience reports · 2026Article
- Protective Effects of Hesperidin on Letrozole-Induced Neurotoxicity: Involvement of Oxidative Stress, Apoptotic Signaling, and Inflammation.Journal of biochemical and molecular toxicology · 2026Article
- Review
- Review
- Hesperidin Inhibits Lung CancerFrontiers in pharmacology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hesperidin (HSD) is a natural compound with antioxidant potential. On the other hand, chronic stress had been linked to impaired cognitive functions as it affects many neurotransmitters and brain regions such as the hippocampus. The current study was conducted to examine the effect of HSD on learning and memory after chronic mild stress. Albino Wistar rats were subjected to chronic mild stress with HSD administered as supplements. HSD was found to decrease hippocampal amyloid beta and malondialdehyde levels, in addition, to preserve cognitive functions together with preserving hippocampus histological architecture. In conclusion, the present study sheds the light on the potential of HSD to ameliorate the deleterious effects of chronic mild stress on cognitive functions through brain-derived neurotrophic factor enhancement and reduction in Aβ formation in addition to activation of the antioxidant pathway.
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Registered trials
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