ArticleClinical oral investigations2022
Microbiome differences in periodontal, peri-implant, and healthy sites: a cross-sectional pilot study.
Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06150066 (Evaluation of the Role of Smoking in the Peri-implantitis Pathogenesis), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Role of Smoking in the Peri-implantitis Pathogenesis
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Transcriptomic and Metagenomic Biomarkers in Peri-Implantitis: A Systematic Review, Diagnostic Meta-Analysis, and Functional Meta-Synthesis.Medical sciences (Basel, Switzerland) · 2025Pooled it
- Clinical, Immunological and Microbiological Improvements With Zinc-Coated Healing Abutments During the Healing Phase.International dental journal · 2026Trial
- Changes in oral microflora following 0.3% cetylpyridinium chloride-containing mouth spray intervention in adult volunteers after professional oral care: Randomized clinical study.Clinical and experimental dental research · 2023Trial
- The association between Trichomonas tenax and Entamoeba gingivalis and periimplantitis and periodontitis.Clinical oral investigations · 2026Article
- Peri-Implantitis and Periodontitis: Biological Convergence, Contextual Divergence.Journal of periodontal research · 2026Review
- Submucosal microbiota profile in peri-implant health, peri-implant mucositis, and different severity levels of peri-implantitis.BMC oral health · 2026Article
- Oral microbiome profiles by periodontitis stage in a Korean population.Frontiers in cellular and infection microbiology · 2026Article
- Comparative analysis of the microbiota in gingival crevicular fluid from peri-implantitis and periodontitis using 16 S ribosomal RNA gene amplicon sequencing: a cross-sectional study.BMC oral health · 2025Article
- Microbial changes in different parts of the oral cavity during the early stage of clear aligner treatment: a preliminary study.Clinical oral investigations · 2025Article
- Postmenopausal osteoporosis increases periodontal inflammation and the pathogenicity of the oral microbiota in a rat model.Journal of oral microbiology · 2025Article
- A scoping review of diagnostic techniques used for the detection of peri-implantitis around endosseous dental implants.Frontiers in dental medicine · 2025Review
- Linking peri-implantitis to microbiome changes in affected implants, healthy implants, and saliva: a cross-sectional pilot study.Frontiers in cellular and infection microbiology · 2025Article
- Microbiological and functional traits of peri-implant mucositis and correlation with disease severity.mSphere · 2024Article
- Experimental models for peri-implant diseases: a narrative review.Clinical oral investigations · 2024Review
- The Peri-Implant Microbiome-A Possible Factor Determining the Success of Surgical Peri-Implantitis Treatment?Dentistry journal · 2024Article
- Microbiome of diseased and healthy implants-a comprehensive microbial data analysis.Frontiers in cellular and infection microbiology · 2024Article
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- Article
- The Microbiome of Peri-Implantitis: A Systematic Review of Next-Generation Sequencing Studies.Antibiotics (Basel, Switzerland) · 2023Review
- Characteristics of oral microbiota and oral health in the patients treated with clear aligners: a prospective study.Clinical oral investigations · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore microbial communities associated with health and disease status around teeth and dental implants. MATERIALS AND
methodsA total of 10 healthy, 24 periodontitis, and 24 peri-implant sites from 24 patients were sequenced by next-generation sequencing. Microbial DNA was extracted and 16S rRNA gene was amplified. Bioinformatic analyses were performed using quantitative insights into microbial ecology (QIIME), linear discriminant analysis effect size (LEfSE), and STAMP.
resultsDifferences in microbial diversity across three types of sites were not statistically significant. Several genera and species were more prevalent in healthy compared with diseased sites, including Lautropia, Rothia and Capnocytophaga and Kingella. Among diseased sites, Peptostreptococcaceae, Dialister, Mongibacterium, Atopobium, and Filifactor were over-represented in peri-implantitis sites, while Bacteroidales was more abundant in periodontitis sites.
conclusionsDiseased periodontal and peri-implant sites and corresponding healthy sites have distinct microbiological profiles. These findings suggest that microbial analyses could identify biomarkers for periodontal health and disease and lead to the development of new strategies to improve periodontal health and treat peri-implant and periodontal diseases. CLINICAL RELEVANCE: The study contributes to improving our understanding of healthy, periodontally affected, and peri-implantitis sites which can improve our ability to diagnose, monitor, and manage these oral conditions.
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