ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2022
Identification and characterization of a natural polymorphism in FT-A2 associated with increased number of grains per spike in wheat.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Spatial transcriptomics identifies distinct domains regulating yield-component traits of the wheat ear.Science advances · 2026Article
- Regulation of spikelet number during wheat spike development.bioRxiv : the preprint server for biology · 2026Article
- The CONSTANS-like gene family in wheat is involved in heading date and drought stress response.Scientific reports · 2025Article
- Identification of robust yield quantitative trait loci derived from cultivated emmer for durum wheat improvement.The plant genome · 2025Article
- Natural alleles of LEAFY and WAPO1 interact to regulate spikelet number per spike in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- LEAFY and WAPO1 jointly regulate spikelet number per spike and floret development in wheat.Development (Cambridge, England) · 2024Article
- The Class III Peroxidase geneFrontiers in plant science · 2024Article
- Wheat bZIPC1 interacts with FT2 and contributes to the regulation of spikelet number per spike.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Sequencing 4.3 million mutations in wheat promoters to understand and modify gene expression.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Wheat plant height locusProceedings of the National Academy of Sciences of the United States of America · 2023Article
- A second-generation capture panel for cost-effective sequencing of genome regulatory regions in wheat and relatives.The plant genome · 2023Article
- A 'wiring diagram' for sink strength traits impacting wheat yield potential.Journal of experimental botany · 2023Review
- Overexpression of the WAPO-A1 gene increases the number of spikelets per spike in bread wheat.Scientific reports · 2022Article
- QTL mapping of yield components and kernel traits in wheat cultivars TAM 112 and Duster.Frontiers in plant science · 2022Article
- WAPO-A1 is the causal gene of the 7AL QTL for spikelet number per spike in wheat.PLoS genetics · 2022Article
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
key messageWe discovered a natural FT-A2 allele that increases grain number per spike in both pasta and bread wheat with limited effect on heading time. Increases in wheat grain yield are necessary to meet future global food demands. A previous study showed that loss-of-function mutations in FLOWERING LOCUS T2 (FT2) increase spikelet number per spike (SNS), an important grain yield component. However, these mutations were also associated with reduced fertility, offsetting the beneficial effect of the increases in SNS on grain number. Here, we report a natural mutation resulting in an aspartic acid to alanine change at position 10 (D10A) associated with significant increases in SNS and no negative effects on fertility. Using a high-density genetic map, we delimited the SNS candidate region to a 5.2-Mb region on chromosome 3AS including 28 genes. Among them, only FT-A2 showed a non-synonymous polymorphism (D10A) present in two different populations segregating for the SNS QTL on chromosome arm 3AS. These results, together with the known effect of the ft-A2 mutations on SNS, suggest that variation in FT-A2 is the most likely cause of the observed differences in SNS. We validated the positive effects of the A10 allele on SNS, grain number, and grain yield per spike in near-isogenic tetraploid wheat lines and in an hexaploid winter wheat population. The A10 allele is present at very low frequency in durum wheat and at much higher frequency in hexaploid wheat, particularly in winter and fall-planted spring varieties. These results suggest that the FT-A2 A10 allele may be particularly useful for improving grain yield in durum wheat and fall-planted common wheat varieties.
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