ArticleMagnetic resonance in medicine2022
Correlated functional connectivity and glucose metabolism in brain white matter revealed by simultaneous MRI/positron emission tomography.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The disappointment centre of the brain gets exciting: a systematic review of habenula dysfunction in depression.Translational psychiatry · 2024Pooled it
- The nature and interpretation of BOLD signals in white matter - A review.Magnetic resonance imaging · 2026Review
- Cortical modulation of resting state BOLD signals in white matter.Scientific reports · 2025Article
- Abnormal spontaneous regional white-matter brain activity in patients with obsessive-compulsive disorder.Frontiers in psychology · 2025Article
- Alterations of white matter connectivity in thalamic-frontal pathways associated with inflammation in premenstrual syndrome.Psychoradiology · 2025Article
- Mapping the white-matter functional connectome: a personal perspective.Psychoradiology · 2025Review
- Resting State Brain Networks under Inverse Agonist versus Complete Knockout of the Cannabinoid Receptor 1.ACS chemical neuroscience · 2024Article
- Characterization of resting functional MRI activity alterations across epileptic foci and networks.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Combined functional and structural imaging of brain white matter reveals stage-dependent impairment in multiple system atrophy of cerebellar type.NPJ Parkinson's disease · 2022Article
- Latency structure of BOLD signals within white matter in resting-state fMRI.Magnetic resonance imaging · 2022Article
- Correlated functional connectivity and glucose metabolism in brain white matter revealed by simultaneous MRI/positron emission tomography.Magnetic resonance in medicine · 2022Article
- The White Matter Functional Abnormalities in Patients with Transient Ischemic Attack: A Reinforcement Learning Approach.Neural plasticity · 2022Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeThere has been converging evidence of reliable detections of blood oxygenation level dependent (BOLD) signals evoked by neural stimulation and in a resting state in white matter (WM), within which few studies examined the relationship between BOLD functional signals and tissue metabolism. The purpose of the present study was to explore whether such relationship exists using combined functional MRI and positron emission tomography (PET) measurements of glucose uptake.
methodsFunctional and metabolic imaging data from 25 right-handed healthy human adults (aged 18-23 years, 18 females) were analyzed. Measures, including average resting state functional connectivity (FC) with respect to 82 Brodmann areas, fractional amplitude of low-frequency fluctuations (FALFF), and average fluorodeoxyglucose (FDG) uptake by PET, were computed for 48 predefined WM bundles. Pearson correlations across the bundles and 25 subjects studied were calculated among these measures. Linear mixed effects models were used to estimate the variance explainable by a predictor variable in the absence of inter-subject variations.
resultsAnalysis of six separate imaging intervals found that average FC the bundles was significantly correlated with local FDG uptake (r = 0.25, p < 0.001), and the FC also covaried significantly with FALFF (r = 0.41, p < 0.001). When random effects from inter-subject variations were controlled, these correlations appeared to be medium to strong (r = 0.41 for FC vs. FDG uptake, and r = 0.65 for FALFF vs. FC).
conclusionThis study indicates that BOLD signals in WM are directly related to variations in metabolic demand and engagement with cortical processing and suggests they should be incorporated into more complete models of brain function.
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