Evidence map›Paper›PMID 34825713›Full record

ArticleThe Journal of pathology2022

B7H3 expression and significance in idiopathic pulmonary fibrosis.

Chuling Fang, Andrew E Rinke, Jing Wang, Kevin R Flaherty, Sem H Phan, Tianju Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Immunosenescence in Idiopathic Pulmonary Fibrosis.Journal of inflammation research · 2026
    Review
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Chuling FangDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Andrew E RinkeDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Jing WangDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Kevin R FlahertyDepartment of Division of Pulmonary/Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Sem H PhanDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Tianju LiuDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0002-0069-3009
University of Michigan · USShenzhen University · CN

Funding

The role of Tet1 in myofibroblast differentiationR01HL143339 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, TIANJU · 2021 to 2024
$2.5M
BM alterations in exacerbation of pulmonary fibrosisR01HL138417 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PHAN, SEM H · 2018 to 2021
$2.3M
Resistin-like molecules in pulmonary fibrosisR01HL112880 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PHAN, SEM H · 2013 to 2016
$2.0M
NHLBI NIH HHS R01 HL112880NHLBI NIH HHS R01 HL138417NHLBI NIH HHS R01 HL143339
6 · The paper itself

Abstract

The clinical significance of B7H3 (CD276) and its cleavage product soluble B7H3 (sB7H3) in idiopathic pulmonary fibrosis (IPF) is unknown. Mounting evidence suggests the potential utility of peripheral blood myeloid cell enumeration to predict disease outcome and indicate active lung disease. Here we hypothesized that sB7H3 is involved in regulation of circulating myeloid cells in pulmonary fibrosis. In support of this possibility, both plasma sB7H3 and B7H3

Indexed as

AgedAnimalsB7 AntigensBleomycinCase-Control StudiesCells, CulturedChemokine CCL2ChemotaxisDisease Models, AnimalDisease ProgressionFemaleHumansIdiopathic Pulmonary FibrosisLungMaleMiceB7 AntigensBleomycinCcl2 protein, mouseCD276 protein, humanCd276 protein, mouseChemokine CCL2Receptors, ImmunologicB7H3bone marrowcell migrationinflammationIPFMDSC

Identifiers

PMID34825713
PMCPMC8825693
OpenAlexW3215192391

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.