Evidence map›Paper›PMID 34825617›Full record

Trial reportScience progress2021

Observer's Assessment of Alertness/Sedation-based titration reduces propofol consumption and incidence of hypotension during general anesthesia induction: A randomized controlled trial.

Lihong Chen, Kun Lu, Tongfeng Luo, Huiming Liang, Yuqin Gui, Sanqing Jin

2 registry-linked trialsAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Science progress, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06232980 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluation of Observer Alertness/Sedation Score (OAA/S) and Bispectral Index (BIS) Parameters for Induction of General Anesthesia With Propofol in Geriatric Patients

TypeinterventionalSponsorAnkara City Hospital BilkentRan2023 to 2024Enrolled134ConditionsE03.155.253, Bispectral Index Monitor, HypotensionArmsurological surgical intervention
NCT06685198 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Impact of Different Titration Endpoints of Propofol on Hemodynamics and Stress During the Induction Phase of General Anesthesia

TypeinterventionalSponsorSanQing JinRan2025 to 2025Enrolled258ConditionsAnesthesia, General, HemodynamicsArmsTitrated administration of propofol to an OAA/S score of 1 as the endpoint, Titrated administration of propofol to an OAA/S score of 2 as the endpoint, Titrated administration of propofol to a BIS value ≤ 60 as the endpoint
3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Comparison of propofol aloneWorld journal of methodology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Effect of remimazolamJournal of biomedical research · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lihong ChenDepartment of Anesthesiology, the Sixth Affiliated Hospital, 373651Sun Yat-sen University, Guangzhou, China.ORCID 0000-0001-6883-8027
Kun LuDepartment of Anesthesiology, the Sixth Affiliated Hospital, 373651Sun Yat-sen University, Guangzhou, China.
Tongfeng LuoDepartment of Anesthesiology, the Sixth Affiliated Hospital, 373651Sun Yat-sen University, Guangzhou, China.
Huiming LiangDepartment of Anesthesiology, the Sixth Affiliated Hospital, 373651Sun Yat-sen University, Guangzhou, China.
Yuqin GuiDepartment of Anesthesiology, the Sixth Affiliated Hospital, 373651Sun Yat-sen University, Guangzhou, China.
Sanqing JinDepartment of Anesthesiology, the Sixth Affiliated Hospital, 373651Sun Yat-sen University, Guangzhou, China.ORCID 0000-0003-0919-8247

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Administration of a single propofol bolus dose for anesthesia induction causes hypotension. We included 160 patients (74 males and 86 females; mean age, 42.4 ± 10.7 [range: 18-60] years) with the American Society of Anesthesiologists status I-II undergoing elective surgery under general anesthesia. Using simple randomization, the patients were divided into a conventional group (

Indexed as

HypotensionPropofolAdultAnesthesia, GeneralBlood PressureFemaleHumansIncidenceMaleMiddle AgedPropofoladministration and dosagegeneral anesthesiahypotensionindividuationPropofolrapid sequence induction and intubation

Identifiers

PMID34825617
PMCPMC10360076

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.