Evidence map›Paper›PMID 34825599›Full record

ArticleEuropean journal of ophthalmology2021

Acute corneal graft rejection after anti-severe acute respiratory syndrome-coronavirus-2 vaccination: A report of four cases.

Miltiadis Balidis, Dimitrios Mikropoulos, Zisis Gatzioufas, Penelope B de Politis, Georgios Sidiropoulos, Vassilios Vassiliadis

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Article in European journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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  4. COVID-19 vaccination and corneal allograft rejection- a review.Frontiers in cellular and infection microbiology · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Miltiadis Balidis98022Ophthalmica Eye Institute, Thessaloniki, Greece.
Dimitrios MikropoulosDepartment of Ophthalmology, Faculty of Medicine, 388413Aristotle University of Thessaloniki (AUTH), Thessaloniki, Greece.
Zisis GatzioufasDepartment of Ophthalmology, University Hospital Basel, Basel, Switzerland.
Penelope B de Politis98022Ophthalmica Eye Institute, Thessaloniki, Greece.ORCID https://orcid.org/0000-0001-7839-8897
Georgios Sidiropoulos98022Ophthalmica Eye Institute, Thessaloniki, Greece.
Vassilios Vassiliadis98022Ophthalmica Eye Institute, Thessaloniki, Greece.
Athens Eye Hospital · GRAristotle University of Thessaloniki · GRUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study intends to add to previous reports on acute corneal graft rejection following anti-severe acute respiratory syndrome-coronavirus-2 vaccination, providing data to corroborate a possible causative relationship between anti-COVID-19 immunization and corneal graft rejection, regardless of vaccine or graft type. METHODS AND

resultsThis report describes 4 cases of acute-onset rejection as early as 5 days following the first dose of anti-severe acute respiratory syndrome-coronavirus-2 vaccine types not yet referred for corneal allograft. Patients were individually given the Moderna messenger RNA-1273 COVID-19 vaccine (2 patients) and the AstraZeneca COVID-19 vaccine, Vaxzevria, AZD1222 (2 patients).

conclusionsEven though a direct causative effect is hard to prove, temporal proximity between anti-severe acute respiratory syndrome-coronavirus-2 vaccines of different types and consecutive reports of corneal graft rejection indicates the need for further investigation. Consistent advice must be given to corneal transplant patients regarding such risk.

Indexed as

anti-severe acute respiratory syndrome-coronavirus-2CorneaCOVID-19graftrejectionvaccination

Identifiers

PMID34825599
OpenAlexW3214838572

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.