Evidence map›Paper›PMID 34825585›Full record

ArticleAutism : the international journal of research and practice2022

Menstruation and menopause in autistic adults: Periods of importance?

Annabeth P Groenman, Carolien Torenvliet, Tulsi A Radhoe, Joost A Agelink van Rentergem, Hilde M Geurts

Open access · hybridAbstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

  1. ADHD and Sex Hormones in Females: A Systematic Review.Journal of attention disorders · 2025
    Pooled it
  2. Pooled it
  3. Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026
    Review
  4. Article
  5. The healthcare experiences of middle and older age autistic women in the United Kingdom.Autism : the international journal of research and practice · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. [Advances in research on gender differences in autism spectrum disorders].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
  13. Unmet need for autism-aware care for gynaecological, menstrual and sexual wellbeing.Autism : the international journal of research and practice · 2025
    Article
  14. Review
  15. Article
  16. "A perfect storm": Autistic experiences of menopause and midlife.Autism : the international journal of research and practice · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Annabeth P GroenmanUniversity of Amsterdam, The Netherlands.ORCID 0000-0002-8394-6605
Carolien TorenvlietUniversity of Amsterdam, The Netherlands.
Tulsi A RadhoeUniversity of Amsterdam, The Netherlands.
Joost A Agelink van RentergemUniversity of Amsterdam, The Netherlands.
Hilde M GeurtsUniversity of Amsterdam, The Netherlands.ORCID 0000-0002-4824-9660
University of Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

lay abstractAutism spectrum conditions were once seen as a predominantly male condition, but this has caused research to have little focus on women. Therefore, little is known about menstruation and menopause in autism spectrum conditions. Some smaller studies indicate that autistic individuals might suffer from increased difficulties surrounding these events. This study aimed to investigate whether autistic women experience more frequent premenstrual dysphoric disorder, causing extreme physical, emotional, and functional impairment. In a partly overlapping sample, we also examined whether women with autism spectrum condition experience increased complaints surrounding menopause. We did not find an increased prevalence of premenstrual dysphoric disorder in autism spectrum conditions (14.3%) compared with non-autistic women (9.5%). Those with autism spectrum conditions did experience increased menopausal complaints. These menopausal complaints were associated with higher levels of depression and autistic traits. In non-autistic women, menopausal complaints were associated with increased inattention, hyperactivity/impulsivity (i.e. attention deficit hyperactivity disorder traits), and depression. With this work, we show the important role that major reproductive milestones can have in an autistic woman's life.

Indexed as

Autism Spectrum DisorderAutistic DisorderPremenstrual Dysphoric DisorderAdultFemaleHumansMaleMenopauseMenstruationadultsautism spectrum disordersmenopausemenstruationwomen

Identifiers

PMID34825585
PMCPMC9344571
OpenAlexW3166746716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.