Evidence map›Paper›PMID 34825427›Full record

ArticleAddiction (Abingdon, England)2022

Community-based naloxone coverage equity for the prevention of opioid overdose fatalities in racial/ethnic minority communities in Massachusetts and Rhode Island.

Shayla Nolen, Xiao Zang, Avik Chatterjee, Czarina N Behrends, Traci C Green, Aranshi Kumar, Benjamin P Linas, Jake R Morgan, Sean M Murphy, Alexander Y Walley and 3 more

Abstract read
In one paragraph

Article in Addiction (Abingdon, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shayla NolenDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.ORCID 0000-0002-1740-7435
Xiao ZangDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Avik ChatterjeeGrayken Center for Addiction and Clinical Addiction Research and Education Unit, Section of General Internal Medicine, Boston Medical Center/Boston University School of Medicine, Boston, MA, USA.
Czarina N BehrendsDepartment of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0003-3885-088X
Traci C GreenWarren Alpert School of Medicine of Brown University, Providence, RI, USA.
Aranshi KumarDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Benjamin P LinasSection of Infectious Diseases, Boston Medical Center, Boston, MA, USA.
Jake R MorganDepartment of Health Law, Policy and Management, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-1559-3983
Sean M MurphyDepartment of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0001-9104-0670
Alexander Y WalleyGrayken Center for Addiction and Clinical Addiction Research and Education Unit, Section of General Internal Medicine, Boston Medical Center/Boston University School of Medicine, Boston, MA, USA.
Shapei YanGrayken Center for Addiction and Clinical Addiction Research and Education Unit, Section of General Internal Medicine, Boston Medical Center/Boston University School of Medicine, Boston, MA, USA.
Bruce R SchackmanDepartment of Population Health Sciences, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-1132-2932
Brandon D L MarshallDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.ORCID 0000-0002-0134-7052

Funding

Project 4: Neonatal Abstinence Syndrome (NAS): Fetus to First YearsP20GM125507 · NIGMS · RHODE ISLAND HOSPITAL · PI Ju Nyeong Park · 2018 to 2026
$23.4M
Utilization of health services after engagement with opioid use disorder (OUD) treatment provider by individuals with and without post-traumatic stress disorderP30DA040500 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZACHARY Franklin MEISEL · 2015 to 2026
$20.7M
DAT-18-06 Prevention and Rescue Of Fentanyl and Other Opioid Overdoses Using Optimized Naloxone Distribution Strategies (PROFOUND)U01DA047408 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARSHALL, BRANDON DAVID LEWIS, SCHACKMAN, BRUCE R · 2019 to 2023
$3.5M
Intervention to Increase Naloxone Engagement and Distribution in Community Pharmacies: A Four-State Randomized TrialR01DA045745 · NIDA · BRANDEIS UNIVERSITY · PI GREEN, TRACI C · 2018 to 2021
$3.1M
Improving Naloxone Access and Its Effects on Drug Abuse and OverdosesR01CE002999 · CE · RAND CORPORATION · PI POWELL, DAVID · 2018 to 2020
$1.9M
NCIPC CDC HHS R01 CE002999NIDA NIH HHS P30 DA040500NIDA NIH HHS R01 DA045745NIDA NIH HHS U01 DA047408NIGMS NIH HHS P20 GM125507
6 · The paper itself

Abstract

BACKGROUND AND

aimsOpioid-related overdose death rates continue to rise in the United States, especially in racial/ethnic minority communities. Our objective was to determine if US municipalities with high percentages of non-white residents have equitable access to the overdose antidote naloxone distributed by community-based organizations.

methodsWe used community-based naloxone data from the Massachusetts Department of Public Health and the Rhode Island non-pharmacy naloxone distribution program for 2016-18. We obtained publicly available opioid-related overdose death data from Massachusetts and the Office of the State Medical Examiners in Rhode Island. We defined the naloxone coverage ratio as the number of community-based naloxone kits received by a resident in a municipality divided by the number of opioid-related overdose deaths among residents, updated annually. We used a Poisson regression with generalized estimating equations to analyze the relationship between the municipal racial/ethnic composition and naloxone coverage ratio. To account for the potential non-linear relationship between naloxone coverage ratio and race/ethnicity we created B-splines for the percentage of non-white residents; and for a secondary analysis examining the percentage of African American/black and Hispanic residents. The models were adjusted for the percentage of residents in poverty, urbanicity, state and population size.

resultsBetween 2016 and 2018, the annual naloxone coverage ratios range was 0-135. There was no difference in naloxone coverage ratios among municipalities with varying percentages of non-white residents in our multivariable analysis. In the secondary analysis, municipalities with higher percentages of African American/black residents had higher naloxone coverage ratios, independent of other factors. Naloxone coverage did not differ by percentage of Hispanic residents.

conclusionsThere appear to be no municipal-level racial/ethnic inequities in naloxone distribution in Rhode Island and Massachusetts, USA.

Indexed as

Drug OverdoseOpiate OverdoseOpioid-Related DisordersAnalgesics, OpioidEthnic and Racial MinoritiesEthnicityHumansMassachusettsMinority GroupsNaloxoneNarcotic AntagonistsRhode IslandUnited StatesAnalgesics, OpioidNaloxoneNarcotic Antagonistsaccessibilitynaloxoneopioids, overdose deathsracial disparity, spatial analysis

Identifiers

PMID34825427
PMCPMC8983544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.